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Locomotor‐activating effects of the novel opioids in female and male ICR mice. Abscissae: dose in mg/kg administered SC (log scale). Ordinates: Locomotor‐activating effects expressed as a percent of the methadone E max. Points show mean ± SEM and filled points indicate doses that produced effects significantly greater than vehicle (p < .05). Data were further segregated by sex and analyzed by two‐way ANOVA, and these results are shown in Table S1.
