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. 2023 Jun 15;30(7):1811–1828. doi: 10.1038/s41418-023-01182-5

Fig. 10. Working model showing the role of NKAP and HDAC3 in preventing R-loop formation and genome instability.

Fig. 10

In wild type cells, NKAP and HDAC3 form a complex to block unscheduled R-loop formation. This will help to maintain genome integrity. However, this mechanism is defective in NKAP or HDAC3 deficient cells. Thus, accumulated R-loops results in increased DNA damage and genome instability. Both XPG and XPF are crucial for processing aberrant R-loops. The figure was created with Biorender.com.