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. 2023 Jun 28;13(7):e1318. doi: 10.1002/ctm2.1318

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Screening m6A‐related circAFF2 in colorectal cancer (CRC). (A) The flowchart showing the selection processes of hsa_circ_0001947. (B and C) After the gene sequencing of the radiosensitive and radioresistant tissues of rectal cancer, the heat map and volcano plot (fold change >2, p < .05) of the differential circular RNAs (circRNAs) were analysed. (D) Methylated RNA immunoprecipitation (Me‐RIP) screened the methylation modification of candidate circRNAs. (E) The radiosensitivity of candidate circRNAs in colon cancer HT‐29 and HCT‐116 cells was detected using a colony formation assay preliminarily detected the radiosensitivity of candidate circRNAs in colon cancer HT‐29 and HCT‐116 cells.