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. 2023 Jun 28;13(7):e1318. doi: 10.1002/ctm2.1318

FIGURE 3.

FIGURE 3

CircAFF2 increases the radiosensitivity of colorectal cancer (CRC) cells in vitro and in vivo. Western blot (A) and ELISA assay (B) detected γ‐H2AX expression in circAFF2‐overexpressed or circAFF2‐depleted HCT‐116 and HT‐29 cells after 4 Gy irradiation. (C) One day after 4 Gy irradiation, apoptosis of circAFF2‐overexpressed or circAFF2‐depleted HCT‐116 and HT‐29 cells was examined by flow cytometry. (D) Representative images of collected tumours. (E) Subcutaneous tumour weights in tumour‐bearing mice. (F) Growth curve of subcutaneous tumour in tumour‐bearing mice. (G) Representative images of TUNEL staining in mouse tumour tissue. *** p < .001, ** p < .01, * p < .05.