Table 2.

Segmentation time of reference software vs. manual segmentation.

	Manual	FreeSurfer 7.3	HIPS	ASHS	HippUnfold	HSF
Segmentation time (min)	~300	678.58 (baseline)	N/A	30.10 ± 1.31	29.52 ± 2.35	1.64 ± 0.27

FreeSurfer segmentation time is computed as a reference point for a single HCP-aging subject (0.8 mm iso.). HIPS, ASHS, and HSF timings are mean ±std of segmentations on our complete test set of 25 subjects. Computations are conducted on a machine with an Intel(R) Xeon(R) Gold 6226R CPU @ 2.90 GHz, and an Nvidia A100 GPU.