Table 2.
Echocardiographic Characteristics and Prevalence of Abnormal Diastolic Dysfunction in Survivors of Childhood Cancer Evaluated Longitudinally
| Echo 1 (n = 3,342) | Echo 2 (n = 1,435) | P Valuea | |
|---|---|---|---|
| E/A ratio | 1.56 (1.26-2.01) | 1.36 (1.10-1.74) | 0.57 |
| Septal e’ velocity, cm/s | 12.0 (10.0-14.0) | 10.0 (8.0-12.0) | 0.002 |
| Lateral e’ velocity, cm/s | 15.0 (12.8-17.5) | 14.0 (11.0-16.0) | 0.17 |
| Average E/e’ | 6.64 (5.63-8.01) | 7.38 (6.12-9.38) | < 0.001 |
| TR velocity, m/s | 2.23 (1.99-2.46) | 2.11 (1.69-2.32) | < 0.001 |
| LA volume, mL/m2 | 19.6 (16.0-23.5) | 20.1 (16.4 -24.0) | 0.96 |
| IVSd, mm | 8.7 (7.8-9.8) | 8.8 (7.8-9.8) | <0.001 |
| LVIDd, mm | 44.9 (41.3-48.7) | 44.8 (41.4-48.5) | <0.001 |
| PWd, mm | 8.5 (7.5-9.5) | 8.4 (7.5-9.4) | <0.001 |
| LVEDV, mL | 94.8 (76.9-115.0) | 84.5 (67.7-104.0) | <0.001 |
| LVEDV index, mL/m2 | 51.2 (42.5-59.9) | 44.8 (36.2-53.4) | <0.001 |
| LVESV, mL | 35.8 (28.3-44.8) | 31.6 (25.1-40.9) | <0.001 |
| LVESV index, mL/m2 | 19.2 (15.7-23.2) | 16.6 (13.5-20.9) | <0.001 |
| SV, mL | 57.8 (46.8-71.3) | 51.7 (40.7-63.7) | <0.001 |
| SV index, mL/m2 | 31.2 (25.9-37.2) | 27.4 (21.9-33.0) | <0.001 |
| LV mass, g/m2 | 67.0 (56.5-79.0) | 65.4 (55.7-76.1) | <0.001 |
| LVEF, % | 61.4 (57.2-65.3) | 61.8 (57.0-65.3) | <0.001 |
| GLS, %) | −18.7 ± 3.4 | −18.4 ± 3.7 | 0.80 |
| Diastolic function, % | |||
| Normal | 2,835 (84.8) | 1,210 (84.3) | |
| Grade 1 | 291 (8.7) | 137 (9.6) | |
| Grade 2 | 17 (0.5) | 20 (1.4) | |
| Grade 3 | 88 (2.6) | 19 (1.3) | |
| Indeterminate | 50 (1.5) | 43 (3.0) | |
| Not determined | 61 (1.8) | 6 (0.4) |
Values are median (Q1-Q3) or n (%).
E/A = E velocity divided by A velocity; e’ = mitral annular e’ velocity; E/e’ = E velocity divided by mitral annular e’ velocity; EF = ejection fraction; GLS = global longitudinal strain; IVSd = interventricular septal end diastole; LA = left atrium; LVEDV = left ventricular end-diastolic volume; LVESV = left ventricular end-systolic volume; LVIDd = left ventricular internal diameter end-diastole; PWd = posterior wall end diastole; SV = stroke volume; TR = tricuspid regurgitation; other abbreviations as in Table 1.
The P values are from the age-adjusted linear mixed-effects models.