Table 3.
Multivariable Analyses of Main Outcomes by Renal Function and Type of Oral Anticoagulant
| Event | n | CrCl 15-<30mL/min |
n | CrCl 30-<50 mL/min |
n | CrCl ≥50 mL/min |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Events | HR (95% CI) | P Value | Events | HR (95% CI) | P Value | Events | HR (95% CI) | P Value | ||||
| Stroke/SEEs | ||||||||||||
| Warfarin | 1,291 | 51 (4.0) | ref | — | 2,664 | 101 (3.8) | ref | — | 2,446 | 83 (3.4) | ref | — |
| No OAC use | 305 | 18 (5.9) | 1.80 (1.01-3.20) | 0.047 | 737 | 28 (3.8) | 1.19 (0.77-1.86) | 0.432 | 739 | 16 (2.2) | 0.94 (0.53-1.64) | 0.817 |
| DOAC | 1,869 | 68 (3.6) | 0.89 (0.61-1.29) | 0.541 | 7,360 | 200 (2.7) | 0.75 (0.59-0.96) | 0.024 | 8,380 | 200 (2.4) | 0.76 (0.58-0.98) | 0.037 |
| Major bleeding | ||||||||||||
| Warfarin | 1,291 | 45 (3.5) | ref | — | 2,664 | 74 (2.8) | ref | — | 2,446 | 51 (2.1) | ref | — |
| No OAC use | 305 | 7 (2.3) | 0.65 (0.28-1.48) | 0.306 | 737 | 15 (2.0) | 0.74 (0.42-1.33) | 0.319 | 739 | 5 (0.7) | 0.36 (0.14-0.91) | 0.032 |
| DOAC | 1,869 | 44 (2.4) | 0.67 (0.43-1.03) | 0.065 | 7,360 | 127 (1.7) | 0.64 (0.48-0.86) | 0.003 | 8,380 | 152 (1.8) | 0.91 (0.66-1.26) | 0.572 |
| Intracranial hemorrhage | ||||||||||||
| Warfarin | 1,291 | 26 (2.0) | ref | — | 2,664 | 56 (2.1) | ref | — | 2,446 | 40 (1.6) | ref | — |
| No OAC use | 305 | 5 (1.6) | 0.77 (0.28-2.10) | 0.612 | 737 | 7 (1.0) | 0.50 (0.22-1.13) | 0.096 | 739 | 5 (0.7) | 0.43 (0.16-1.11) | 0.080 |
| DOAC | 1,869 | 26 (1.4) | 0.64 (0.36-1.12) | 0.115 | 7,360 | 90 (1.2) | 0.60 (0.43-0.85) | 0.004 | 8,380 | 107 (1.3) | 0.79 (0.54-1.14) | 0.213 |
| Major plus clinically relevant nonmajor bleeding | ||||||||||||
| Warfarin | 1,291 | 86 (6.7) | ref | — | 2,664 | 112 (4.2) | ref | — | 2,446 | 107 (4.4) | ref | — |
| No OAC use | 305 | 15 (4.9) | 0.80 (0.46-1.38) | 0.419 | 737 | 25 (3.4) | 0.81 (0.52-1.25) | 0.340 | 739 | 9 (1.2) | 0.28 (0.14-0.55) | <0.001 |
| DOAC | 1,869 | 103 (5.5) | 0.82 (0.62-1.10) | 0.186 | 7,360 | 280 (3.8) | 0.90 (0.72-1.12) | 0.336 | 8,380 | 284 (3.4) | 0.77 (0.62-0.96)) | 0.021 |
| All bleeding | ||||||||||||
| Warfarin | 1,291 | 135 (10.5) | ref | — | 2,664 | 233 (8.8) | ref | — | 2,446 | 212 (8.7) | ref | — |
| No OAC use | 305 | 24 (7.9) | 0.70 (0.44-1.09) | 0.113 | 737 | 42 (5.7) | 0.65 (0.47-0.92) | 0.014 | 739 | 19 (2.6) | 0.30 (0.19-0.49) | < 0.001 |
| DOAC | 1,869 | 188 (10.1) | 0.96 (0.76-1.20) | 0.719 | 7,360 | 573 (7.8) | 0.92 (0.79-1.08) | 0.295 | 8,380 | 611 (7.3) | 0.86 (0.73-1.01) | 0.068 |
| Gastrointestinal bleeding | ||||||||||||
| Warfarin | 1,291 | 61 (4.7) | ref | — | 2,664 | 94 (3.5) | ref | — | 2,446 | 91 (3.7) | ref | — |
| No OAC use | 305 | 8 (2.6) | 0.52 (0.24-1.11) | 0.090 | 737 | 27 (3.7) | 1.04 (0.67-1.63) | 0.859 | 739 | 13 (1.8) | 0.50 (0.28-0.91) | 0.023 |
| DOAC | 1,869 | 91 (4.9) | 1.10 (0.78-1.54) | 0.584 | 7,360 | 270 (3.7) | 1.10 (0.87-1.40) | 0.422 | 8,380 | 271 (3.2) | 0.91 (0.71-1.16) | 0.455 |
| Cardiovascular death | ||||||||||||
| Warfarin | 1,291 | 74 (5.7) | ref | — | 2,664 | 78 (2.9) | ref | — | 2,446 | 27 (1.1) | ref | — |
| No OAC use | 305 | 23 (7.5) | 1.61 (0.98-2.63) | 0.058 | 737 | 19 (2.6) | 1.03 (0.61-1.74) | 0.923 | 739 | 5 (0.7) | 0.95 (0.35-2.60) | 0.928 |
| DOAC | 1,869 | 109 (5.8) | 1.11 (0.82-1.50) | 0.510 | 7,360 | 129 (1.8) | 0.67 (0.50-0.90) | 0.007 | 8,380 | 63 (0.8) | 0.84 (0.53-1.33) | 0.452 |
| All-cause death | ||||||||||||
| Warfarin | 1,291 | 204 (15.8) | ref | — | 2,664 | 242 (9.1) | ref | — | 2,446 | 95 (3.9) | ref | — |
| No OAC use | 305 | 72 (23.6) | 1.73 (1.31-2.30) | <0.001 | 737 | 62 (8.4) | 1.08 (0.81-1.45) | 0.586 | 739 | 31 (4.2) | 1.38 (0.90-2.11) | 0.140 |
| DOAC | 1,869 | 292 (15.6) | 1.05 (0.88-1.27) | 0.586 | 7,360 | 459 (6.2) | 0.74 (0.63-0.87) | <0.001 | 8,380 | 293 (3.5) | 1.01 (0.80-1.28) | 0.915 |
| Net clinical outcome | ||||||||||||
| Warfarin | 1,291 | 259 (20.1) | ref | — | 2,664 | 347 (13.0) | ref | — | 2,446 | 181 (7.4) | ref | — |
| No OAC use | 305 | 85 (27.9) | 1.60 (1.24-2.08) | <0.001 | 737 | 87 (11.8) | 1.09 (0.85-1.40) | 0.490 | 739 | 48 (6.5) | 1.12 (0.81-1.57) | 0.488 |
| DOAC | 1,869 | 347 (18.6) | 0.96 (0.82-1.14) | 0.665 | 7,360 | 678 (9.2) | 0.75 (0.66-0.86) | <0.001 | 8,380 | 544 (6.5) | 0.96 (0.81-1.14) | 0.613 |