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Schematic view of human PVT1 gene locus and alternative splicing. PVT1 located in the region of 8q24.21 harboring MYC/PVT1 loci and PVT1-encoded five miRNAs and probable mode of biogenesis of circPVT1. The positive feedback and promoter-enhancer competition between PVT1 and MYC were shown. The rectangles represent the exons.
