Table 1.
Related diseases and miRNAs sponged by PVT1.
| Related diseases | miRNAs | Target genes or signaling pathways | Function | References |
|---|---|---|---|---|
| Acute kidney injury (AKI) | miR-20a-5p | NLRP3 | Modulate NLRP3-mediated pyroptosis | 66 |
| Atrial fibrillation | miR-145-5p | IL-16 | Boost the extracellular matrix remodeling of atrial fibroblasts | 67 |
| Bladder cancer | miR-194-5p | BCLAF1 | Increase malignant phenotypes | 68 |
| Cardiac hypertrophy | miR-196b | OSMR | Knockdown attenuates the myocardial hypertrophy | 69 |
| Cardiotoxicity | miR-187-3p | AGO1 | Aggravate doxorubicin-induced cardiomyocyte apoptosis | 70 |
| Cervical cancer | miR-140-5p | SMAD3 | Promote the proliferation and metastasis | 71 |
| Clear cell renal cell carcinoma (ccRcc) | miR-328-3p | FAM193B | Promote the proliferation of ccRCC cells | 72 |
| Diabetic cataract (DC) | miR-214-3p | MMP2, regulated by SP1 | Modulate the proliferation and apoptosis of lens epithelial cells | 73 |
| Diabetic nephropathy (DN) | miR-23b-3p | WT1 | Knockdown alleviates high glucose-induced proliferation and fibrosis in human mesangial cells | 74 |
| Diabetic osteoarthritis (DOA) | miR-146a | TGF-β/SMAD4 pathway | Promote cartilage degradation | 75 |
| Esophageal squamous cell carcinoma (ESCC) | miR-203 | LASP1 | Promote ESCC progression | 76 |
| Gallbladder cancer (GBC) | miR-143 | HK2 | Knockdown inhibits cell proliferation, migration, and invasion | 77 |
| Gastric cancer | miR-186 | HIF-1α | promoted the GC cell proliferation and invasion | 78 |
| Glioma | miR-128-3p | GREM1 and BMP Signaling Pathway | Promote tumorigenesis and progression | 79 |
| Ischemic stroke | miR-24-3p | STAT3, regulated by SOX2 | Depleting improves ischemic stroke | 80 |
| Myocardial ischemia/reperfusion (I/R) injury | miR-186 | Beclin-1 | Knockdown protects cardiomyocytes apoptosis and autophagy | 81 |
| Neuropathic pain | miR-186-5p | CXCL13/CXCR5 | Depletion alleviates neuropathic pain, astrocytic activation and reduced the expression of neuroinflammatory factors and proteins | 82 |
| Non-small cell lung cancer (NSCLC) | miR-200a and miR-200b | MMP9 | Promote the invasive ability of NSCLC cells | 83 |
| Osteoarthritis (OA) | miR-27b-3p | TRAF3 | Inhibit IL-1β-induced injury in chondrocytes | 84 |
| Osteosarcoma (OS) | miR-497 | HK2 | Contribute to OS cell glucose metabolism, cell proliferation, and motility | 85 |
| Papillary thyroid carcinoma (PTC) | miR-30a | IGF1R | Enhance the viability and invasion | 86 |
| PM2.5-exposed lung cancer | miR-199a-5p | Caveolin 1 | Affect the role of lentinan in PM2.5-exposed lung cancer cells | 87 |
| Pulpitis | miR-455-5p | SOCS3 and PLXNC1 | Involve in the pathogenesis of pulpitis | 88 |
| Retinoblastoma (RB) | miR-488-3p | NOTCH2 | Silencing inhibits cell proliferation, migration, invasion, and cell cycle progression and induces cell apoptosis | 89 |
| Rheumatoid arthritis (RA) | miR-543 | SCUBE2 | Regulate apoptosis of fibroblast-like synoviocytes | 90 |
| RSV-infected asthma | miR-203a | E2F3 | Involve in the mechanism of α-asarone in treating RSV-induced asthma | 91 |
| Temporomandibular joint osteoarthritis (TMJ OA) | miR-211-3p | TNF-α | Induce chondrocyte apoptosis | 92 |