Table 2.
Related diseases and miRNAs sponged by circPVT1.
| Related diseases | miRNAs | Target genes or signaling pathways | Function | References |
|---|---|---|---|---|
| Adenomyosis (ADS) | miR-145 | TALIN1 | Promote eutopic endometrial cell proliferation and invasion | 99 |
| Breast cancer (BCa) | MiR-29a-3p | AGR2-HIF-1α Pathway | Promote the progression of breast cancer | 100 |
| Clear cell renal cell carcinoma (ccRcc) | miR-145-5p | TBX15 | Promote ccRCC growth and metastasis | 101 |
| Colorectal cancer (CRC) | let-7 | NRAS | Drive cancer cells towards oncogenicity | 102 |
| Epithelial ovarian cancer (EOC) | miR-149 | NR | Enhance cell proliferation but inhibits apoptosis | 103 |
| Esophageal carcinoma (EC) | miR-4663 | PAXs and PPARs | Promote cell invasive ability | 104 |
| Gastric cancer (GC) | miR-124-3p | ZEB1 | Contribute to paclitaxel resistance of gastric cancer cells | 105 |
| Hepatocellular carcinoma (HCC) | miR-3666 | SIRT7 | Promote HCC cell growth | 106 |
| Lung adenocarcinoma (LADC) | miR-429 | FOXK1 | Interference inhibits the progression of lung ADC and enhances its sensitivity to DDP | 107 |
| Lung squamous cell carcinoma (LUSC) | miR-30d and miR-30e | CCNF, regulated by HuR | Promote the proliferation of LUSC cells | 108 |
| Myocardial infarction (MI) | miR-125b,miR-200a | p53/Traf6, Sirt7, Keap 1/Nrf 2, and PDCD4 | Apoptotic signaling | 109 |
| Neck squamous cell carcinoma (HNSCC) | miR-497-5p | P53/YAP/TEAD | Increase the malignant phenotype | 110 |
| Non-small cell lung cancer (NSCLC) | miR-125b | E2F2 | Promote NSCLC cell growth and invasion | 111 |
| Oral squamous cell carcinoma (OSCC) | miR-125b | STAT3 | Regulate cell proliferation | 112 |
| Osteosarcoma (OS) | miR-137 | TRIAP1 | Boosted doxorubicin (DXR) resistance | 113 |
| Senescence | let-7 | IGF2BP1, KRAS and HMGA2 | Silencing promotes cell senescence and reverses the proliferative phenotype | 98 |
| Steroid-induced osteonecrosis of the femoral head (SIONFH) | miR-21-5p | SMAD7/TGFβ signaling pathway | Attenuate the apoptosis and cell viability inhibition | 114 |
| T cell acute lymphoblastic leukemia (T-ALL) | miR-30e | DLL4-NOTCH signaling | Knockdown inhibits the cell proliferation and increase the cell apoptosis | 115 |