Figure 1.

The structure of CDO1 enzyme active center and sequence alignment of CDO1 proteins among species. (A) The enzyme active center structure of CDO1 protein. The mononuclear iron center is coordinated with the Nε2 atoms of three histidine ligands (His,⁸⁶ His,⁸⁸ and His¹⁴⁰) and water molecules bound to the catalytic iron. (B) Comparison of CDO1 protein sequences of human, bos taurus, caenorhabditis elegans and mouse. Among the 4 sequences, 2 identical residues are represented in blue; 3 identical residues are represented in red; 4 identical residues are represented in black.