Figure 6.

The effect of CDO1 on neurodegenerative disorders, obesity and metabolic disorders. Aberrant accumulation of cysteine can lead to neurotoxicity. Furthermore, accumulated cysteine may chelate iron, leading to the local increase in iron content. The combined excess of cysteine and ferrous iron would generate free radicals that damage neurons. Therefore, CDO1 can improve neurodegenerative disorders by promoting cysteine catabolism. On the other hand, CDO1 can improve obesity and metabolic disorders by promoting taurine production, which in turn inhibits plasma lipid content and facilitates the browning of white fat. Fe, local iron level.