TABLE 2.
Multivariable-adjusted1 mean concentration (95% CI) of serum lipid biomarkers in tertiles of EDIP-HALST scores among participants who did not take dyslipidemia medications
| T1 |
T2 |
T3 |
Per unit increment |
P-trend2 | FDR P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean1 | 95% CI | Mean1 | 95% CI | Mean1 | 95% CI | Mean1 | 95% CI | ||||
| Men, n | 759 | 766 | 768 | ||||||||
| Total cholesterol (mg/dL) | 177 | (173, 182) | 179 | (175, 184) | 180 | (175, 184) | 0.44 | (−0.29, 1.18) | 0.26 | 0.29 | |
| HDLC (mg/dL) | 46.2 | (44.8, 47.7) | 45.0 | (43.7, 46.4) | 45.4 | (44.1, 46.8) | −0.39% | (−0.87%, 0.09%) | 0.11 | 0.16 | |
| LDLC (mg/dL) | 109 | (105, 114) | 110 | (106, 114) | 112 | (107, 116) | 0.40 | (−0.27, 1.06) | 0.29 | 0.29 | |
| TGs (mg/dL) | 97.2 | (90.9, 104) | 104 | (97.5, 111) | 105 | (98.5, 112) | 1.62% | (0.58%, 2.67%) | <0.01 | 0.01 | |
| TGs/HDLC | 2.10 | (1.93, 2.29) | 2.32 | (2.14, 2.52) | 2.31 | (2.13, 2.50) | 2.01% | (0.68%, 3.37%) | <0.01 | 0.01 | |
| TGs/total cholesterol | 0.557 | (0.522, 0.594) | 0.595 | (0.558, 0.633) | 0.596 | (0.560, 0.634) | 1.42% | (0.41%, 2.43%) | <0.01 | 0.01 | |
| Women, n | 818 | 813 | 842 | ||||||||
| Total cholesterol (mg/dL) | 191 | (184, 199) | 191 | (183, 198) | 190 | (183, 198) | −0.22 | (−1.02, 0.59) | 0.58 | 0.58 | |
| HDLC (mg/dL) | 51.6 | (49, 54.2) | 50.9 | (48.4, 53.5) | 50.7 | (48.2, 53.3) | −0.39% | (−0.90%, 0.14%) | 0.15 | 0.22 | |
| LDLC (mg/dL) | 117 | (110, 124) | 117 | (110, 124) | 116 | (109, 123) | −0.30 | (−1.04, 0.44) | 0.41 | 0.49 | |
| TGs (mg/dL) | 110 | (99.1, 122) | 113 | (102, 125) | 115 | (104, 128) | 0.97% | (−0.13%, 2.08%) | 0.08 | 0.16 | |
| TGs/HDLC | 2.14 | (1.86, 2.45) | 2.21 | (1.93, 2.53) | 2.27 | (1.99, 2.60) | 1.36% | (−0.06%, 2.80%) | 0.06 | 0.16 | |
| TGs/total cholesterol | 0.586 | (0.529, 0.650) | 0.601 | (0.543, 0.665) | 0.616 | (0.557, 0.682) | 1.09% | (0.01%, 2.17%) | 0.04 | 0.16 | |
Abbreviations: EDIP, empirical dietary inflammatory pattern; FDR, false-discovery rate; HALST, the Healthy Aging Longitudinal Study in Taiwan.
Means were adjusted for age at recruitment (continuous), center, education (low literacy, primary school, middle school and above), smoking (never, former, and current), alcohol consumption (never, former, and current), physical activity at leisure time and at work (sex-specific quartile), BMI (<18.5, 18.5 to <25, 25 to <30, and ≥30 kg/m2), treatment for hypertension (yes and no), and diabetes (yes and no). The dependent variables were log-transformed before fitting a multiple linear regression, except for the total cholesterol and LDLC. The adjusted means were then calculated by exponentiating the adjusted natural-log transformed means. The adjusted means per unit increment were calculated by exponentiating the adjusted natural-log transformed means minus 1 and multiplied by 100, thus should be interpreted as “relative change.”
The P value for the linear trend was calculated by modeling the median values of each category as continuous variables and adjusted for all covariates listed in footnote 1.