Table 1.
Item | Description |
Mitochondrial biogenesis | PPAR-γ coactivator 1-α, nuclear respiratory factor 1, mitochondrial transcription factor A. Material obtained from tissue biopsy or from peripheral PBMC |
Mitochondrial content | Mitochondrial mass, concentration and area |
Mitochondrial DNA content | PGC-1α, NRF-1, absolute DNA number of copies |
Mitochondrial fusion | Mitofusins 1 and 2, optic atrophy 1 protein |
Mitochondrial fission | Dynamin-related protein 1 and fission 1 protein |
PPAR-γ: Peroxisome proliferator-activated receptor gamma; PGC-1α: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha; NRF-1: Nuclear respiratory factor-1; PBMC: Peripheral blood mononuclear cells.