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. 2023 May 19;42(13):e112504. doi: 10.15252/embj.2022112504

Figure EV2. Alignments, phylogenetic tree, and structural conservation of the Ndc80 kink and loop.

Figure EV2

  1. Sequence alignment of the loop region of the NDC80 subunit in various species. Residue numbers correspond to the human NDC80.
  2. Unrooted phylogenetic tree that was generated with complete NDC80 sequences. Sequences in panel (A) were arranged according to this tree. Species belonging to the Chordata phylum (light green) and the Fungi kingdom (purple) are indicated. Black dots mark species for which we predicted the structure.
  3. Predicted structures of the NDC80:NUF2 region spanning the hinge and loop regions. Shown in similar orientations following structural alignment to the human fragment NDC80376–516:NUF2269–356.

Source data are available online for this figure.