Table 10. Effect of the Hydro-Methanolic Extract of C. hirsuta on Oxidative Stress Marker.
| MDA content (nmol/mg prot.) | NC | HFD-STZ | HFD-STD | HFD-500 mg/kg | HFD-250 mg/kg | HFD-125 mg/kg |
|---|---|---|---|---|---|---|
| pancreas | 2.21 ± 0.0114 | 3.99 ± 0.0321***### | 2.32 ± 0.0249** | 2.48 ± 0.0693***### | 2.48 ± 0.0195***### | 2.43 ± 0.0228***## |
| liver | 3.33 ± 0.0404 | 5.56 ± 0.329***### | 3.58 ± 0.0958 | 3.65 ± 0.0396* | 3.77 ± 0.0801** | 3.78 ± 0.0779*** |
| kidney | 1.44 ± 0.023 | 3.76 ± 0.0212***### | 1.53 ± 0.027 | 1.96 ± 0.023***### | 2.71 ± 0.178***### | 2.44 ± 0.48**# |
| blood serum (nmol/mL) | 2.33 ± 0.0445 | 5.65 ± 0.193***### | 2.84 ± 0.167*** | 3.03 ± 0.151**** | 4.21 ± 0.198***### | 4.02 ± 0.0487***### |
| SOD Activity (U/mg Protein) | ||||||
| pancreas | 337 ± 25.3 | 79.7 ± 39***### | 241 ± 25.2*** | 204 ± 7.24*** | 164 ± 5.92***### | 135 ± 14.4***### |
| liver | 369 ± 34.7 | 152 ± 26.3***### | 329 ± 29.6 | 314 ± 52.7 | 247 ± 14.3***# | 210 ± 35.3***### |
| kidney | 289 ± 7.5 | 71.8 ± 9.45***### | 230 ± 14.3*** | 211 ± 21.4*** | 91.9 ± 4.17***### | 84.5 ± 4.47***### |
| blood serum (U/mL) | 313 ± 39.4 | 138 ± 4.66***### | 293 ± 10.1 | 285 ± 9.98 | 244 ± 16.3***# | 161 ± 27.6***### |
| T.AOC Activity (U/mg) | ||||||
| pancreas | 2.81 ± 0.0339 | 1.138 ± 0.2329***### | 2.526 ± 0.05413* | 2.48 ± 0.04848* | 2.194 ± 0.1658***# | 1.344 ± 0.1841***### |
| liver | 3.48 ± 0.121 | 1.32 ± 0.191***### | 2.37 ± 0.157*** | 2.55 ± 0.0626*** | 2.16 ± 0.0396*** | 1.92 ± 0.14***### |
| kidney | 2.47 ± 0.103 | 0.458 ± 0.0223***### | 1.91 ± 0.181** | 1.54 ± 0.0293*** | 1.02 ± 0.408***### | 1.2 ± 0.232***### |
| blood serum (nmol/mL) | 78.6 ± 6.86 | 23.8 ± 1.3***### | 85.8 ± 10.3 | 56.3 ± 0.652***### | 55.4 ± 2.9***### | 46.5 ± 0.939***### |
| GSH-ST Activity (U/mg Protein) | ||||||
| pancreas | 8.47 ± 0.247 | 4.15 ± 0.0399***### | 6.34 ± 0.265 | 5.76 ± 0.299***## | 5.36 ± 0.239***### | 5 ± 0.112***### |
| liver | 18.2 ± 0.223 | 4.14 ± 0.0929***### | 16.8 ± 0.378*** | 15.4 ± 0.324***### | 15.1 ± 0.0973***### | 13.2 ± 0.894***### |
| kidney | 8.8 ± 0.332 | 4.16 ± 0.111***### | 6.86 ± 0.187*** | 5.81 ± 0.294***#### | 5.41 ± 0.259***### | 5.2 ± 0.158***### |
| blood serum (U/mL) | 9.1 ± 1.62 | 3.7 ± 0.474***### | 8.7 ± 0.673 | 5.82 ± 0.622***### | 5.27 ± 0.0565***### | 5.06 ± 0.0932***### |
| GS-PX Activity (U) | ||||||
| pancreas | 1131 ± 92.13 | 865 ± 37.42***### | 1113 ± 2.074 | 1092 ± 1.074 | 1061 ± 21.95 | 1079 ± 44.58 |
| liver | 560 ± 1.11 | 380 ± 40.3***### | 556 ± 6.59 | 534 ± 23.3 | 504 ± 36***# | 459 ± 18.1***#### |
| kidney | 47.1 ± 1.39 | 24.7 ± 3.85***### | 45.6 ± 0.965 | 43.1 ± 1.46 | 42.7 ± 0.694* | 35.6 ± 2.21***### |
| blood serum | 688 ± 164.4 | 355.7 ± 40.12** | 580.4 ± 160.4 | 634.1 ± 161.8 | 626.6 ± 152.9 | 622.2 ± 36.7 |
| Catalase Activity (U/g Protein) | ||||||
| pancreas | 21.6 ± 1.06 | 12.7 ± 2.21*** | 19.9 ± 0.665 | 18.4 ± 0.39** | 17.3 ± 0.76***# | 16.2 ± 0.757***### |
| liver | 477 ± 19 | 266 ± 34.1### | 467 ± 21.6*** | 456 ± 23.6 | 414 ± 11.7**## | 398 ± 5.74***### |
| kidney | 58.9 ± 1.25 | 23.8 ± 1.4***### | 56.1 ± 0.976 | 55.4 ± 0.402* | 52.5 ± 0.469***# | 48.4 ± 3.38***### |
| whole blood (U/g Hb) | 161 ± 29.7 | 94.8 ± 8.35***## | 132 ± 6* | 129 ± 6.02** | 111 ± 2.3*** | 106 ± 7.3***# |
| serum G6PD conc. % | 83.4 ± 3.44 | 25.4 ± 1.14***### | 81.8 ± 2.17 | 79 ± 1.58# | 71 ± 1.58***### | 67 ± 1.58***### |