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. 2023 Jun 29;24:270. doi: 10.1186/s12859-023-05391-0

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Multidimensional analysis between KLF2 expression and immune microenvironment in HCC. A KLF2 expression positively correlated with stromal score, immune score, and ESTIMATE score in HCC. B KLF2 expression is significantly positively related to infiltrating levels of CD4⁺ T cells, CD8⁺ T cells, B cells, dendritic cells, macrophages, and neutrophils in HCC. C Heat map of the correlation between the expression of KLF2 and immune-checkpoint-related genes. The different colors represent the trend of gene expression in different samples. D Correlation analysis between KLF2 gene expression and TMB. E, F Scatter plots show KLF2 expression is associated with PDCD1 and CD274. G, H Comparison of response to ICB treatments in KLF2 high- and low-expression groups. I, J Prognostic KM curves of high- and low-expression groups of KLF2. *P < 0.05, **P < 0.01, ***P < 0.001