Extended Data Table 1.
Study-related SAEs following CART-PSMA-TGFβRDN cell infusion
| SAE Grade | |||||
|---|---|---|---|---|---|
| Cohort 2 (n = 3) | 1 | 2 | 3 | 4 | 5 |
| Cytokine Release Syndrome (CRS) | 0 | 0 | 2 | 0 | 0 |
| Encephalopathy | 0 | 0 | 1 | 0 | 0 |
| Syncope | 0 | 0 | 1 | 0 | 0 |
| Acute Kidney Injury | 0 | 0 | 1 | 0 | 0 |
| Hypotension | 0 | 0 | 1 | 0 | 0 |
| Cohort 3 (n = 1) | 1 | 2 | 3 | 4 | 5 |
| Anemia | 0 | 0 | 1 | 0 | 0 |
| Disseminated Intravascular Coagulation | 0 | 0 | 1 | 0 | 0 |
| Hepatic Failure | 0 | 0 | 1 | 0 | 0 |
| Cytokine Release Syndrome | 0 | 0 | 0 | 1 | 0 |
| Acute Kidney Injury | 0 | 0 | 0 | 1 | 0 |
| Respiratory Failure | 0 | 0 | 0 | 1 | 0 |
| Hypotension | 0 | 0 | 0 | 1 | 0 |
| Cohort −3 (n = 6) | 1 | 2 | 3 | 4 | 5 |
| Cytokine Release Syndrome | 1 | 2 | 0 | 0 | 0 |
| Upper Respiratory Infection | 0 | 0 | 1 | 0 | 0 |
| Renal and Urinary Disorders - Other (SIADH*) | 0 | 0 | 1 | 0 | 0 |
| Hypoxia | 0 | 0 | 1 | 0 | 0 |
| Hypotension | 0 | 0 | 1 | 0 | 0 |
*
Syndrome of innaproriate antidiuretic hormone secretion