Extended Data Table 2.
Individual patient SAEs following CART-PSMA-TGFβRDN cell infusion
| Subject ID | Cohort | CART-PSMA-TGFβRDN Cell Attribution | Toxicity | Grade | Duration (Days) | Time from Infusion to Event (Days) |
|---|---|---|---|---|---|---|
| Patient 2 | 1 | Unrelated | Hematuria | 4 | 52 | 26 |
| Patient 5 | 1 | Unrelated | Hip fracture | 3 | 2 | 14 |
| Patient 6 | 2 | Definitely | Cytokine release syndrome | 3 | 3 | 0 |
| Probably | Encephalopathy | 3 | 4 | 0 | ||
| Possibly | Syncope | 3 | 1 | 17 | ||
| Possibly | Acute kidney injury | 3 | 3 | 30 | ||
| Patient 7 | 2 | Definitely | Cytokine release syndrome | 3 | 3 | 0 |
| Probably | Hypotension | 3 | 2 | 1 | ||
| Patient 8 | 2 | Unrelated | Urinary tract infection | 3 | 7 | 26 |
| Patient 9 | 3 | Definitely | Cytokine release syndrome | 4 | 9 | 0 |
| Probably | Hypotension | 4 | 8 | 1 | ||
| Probably | Respiratory failure | 4 | 28 | 2 | ||
| Possibly | Anemia | 3 | 26 | 4 | ||
| Possibly | Disseminated intravascular coagulation | 3 | 26 | 4 | ||
| Probably | Acute kidney injury | 4 | 24 | 6 | ||
| Probably | Hepatic failure | 3 | 24 | 6 | ||
| Unrelated | Sepsis | 5 | 10 | 20 | ||
| Patient 11 | −3 | Definitely | Cytokine release syndrome | 2 | 2 | 0 |
| Probably | Hypoxia | 3 | 2 | 0 | ||
| Patient 12 | −3 | Definitely | Cytokine release syndrome | 2 | 8 | 0 |
| Patient 14 | −3 | Definitely | Cytokine release syndrome | 1 | 3 | 25 |
| Possibly | Renal and urinary disorders - other (SIADH) | 3 | 5 | 26 | ||
| Patient 17 | −3 | Possibly | Hypotension | 3 | 2 | 9 |
| Possibly | Upper respiratory infection | 3 | 5 | 9 |