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. 2023 May 18;97(6):e00635-23. doi: 10.1128/jvi.00635-23

FIG 1.

FIG 1

s2m nucleotide sequence alignment. (A) Multiple-sequence alignment of representative coronaviruses in the Betacoronavirus, Gammacoronavirus, and Deltacoronavirus genera that encode an s2m. (B) Sequence alignment of the s2m element found in SARS-CoV-2 isolates. SARS-CoV-2-WT is the original SARS-CoV-2 isolate (GenBank accession no. NC_045512), SARS-CoV-2-WUSTL is the virus isolated from the patient in the St. Louis area (2019-nCoV/WUSTL_000226/2020), SARS-CoV-2-s2mΔ8–33 is the circulating s2m deletion mutant, SARS-CoV-2-s2m2–5 is the engineered s2m stem structure mutant, SARS-CoV-2-s2m2–5,39–42 is the engineered s2m stem structure mutation revertant, and SARS-CoV-2-s2mΔ2–42 is the engineered s2m deletion mutant. The genomic coordinates for the SARS-CoV-2-WT are indicated. (C) SARS-CoV-2 s2m deletion-containing sequences found by release date.