FIG 6.
Superfold analysis of the 3′ UTR of wild type and SARS-CoV-2-s2mΔ2–42. Following the probing of viral genome in purified SARS-CoV-2 virions, the SHAPE-MaP and DMS-MaPseq reactivity profiles were determined as described in Materials and Methods. SuperFold was used to predict consensus secondary structure prediction with base-pairing probabilities using the SHAPE-MaP (A and C) and DMS-MaPseq (B and D) reactivity profiles for wild-type SARS-CoV-2 (A and B) and SARS-CoV-2-s2mΔ2–42 (C and D). Nucleotides 29729 to 29768 were deleted from the CoV-2-s2mΔ2–42 genome.