TABLE 2.
Levels of HIV DNA in brain and lymphoid tissues
| Parameter | Data by category |
|||||
|---|---|---|---|---|---|---|
| All (n = 63) |
Female (n = 12, 19%) |
Male (n = 51, 81%) |
||||
| gag | 2-LTR | gag | 2-LTR | gag | 2-LTR | |
| HIV DNA gag and 2-LTRa | ||||||
| Frontal cortex | 69.8 (44/63) | 22.2 (14/63) | 75 (9/12) | 41.6 (5/12) | 68.6 (35/51) | 17.6 (9/51) |
| Occipital cortex | 55.4 (31/56) | 21.4 (12/56) | 75 (9/12) | 33.3 (4/12) | 50 (22/44) | 11.4 (5/44) |
| Basal ganglia | 69.5 (41/59) | 27.1 (16/59) | 81.8 (9/11) | 54.5 (6/11) | 66.7 (32/48) | 20.8 (10/48) |
| Lymphoid tissue | 100 (59/59) | 57.6 (34/59) | 100 (9/9) | 55.5 (5/9) | 100 (50/50) | 58 (29/50) |
| HIV DNA gag and 2-LTR (cps/million cells)b | ||||||
| Frontal cortex | 186.3 (1.5–2,968.1) | 44.4 (1.4–284.7) | 187.8 (4.2–1,270.7) | 22.4 (5.2–78.3) | 163.7 (1.5–2,968.1) | 56.6 (1.4–284.7) |
| Occipital cortex | 78.5 (2.5–1,401.6) | 15.9 (2.7–50.9) | 177.6 (2.8–1,401.6) | 14.9 (2.7–40.3) | 37.9 (2.5–283.9) | 16.6 (3.3–50.9) |
| Basal ganglia | 230.5 (1.6–2,120.2) | 32.4 (2.1–172.8) | 423.4 (2.5–2,120.2) | 39 (2.1–172.8) | 183.5 (1.6–2,096.4) | 28.4 (3.2–107.6) |
| Lymphoid tissue | 364.7 (7.3–3,741.9) | 29.9 (1–171) | 501.1 (12.2–2,801.6) | 53.5 (2–171) | 313.7 (7.3–3,741.9) | 26.5 (2.6–149.1) |
a
Data are shown as % (n of positive/available processed samples).
b
Data are shown as mean (range) of detectable samples.