FIG 7.

Top significantly enriched pathways altered in the spleen in response to RVFV infection (2 days post-infection). (A) Gene Ontology (GO) biological process (left) and molecular function (right) over-representation analysis of genes differentially expressed in RVFV-infected spleen tissue. The dot size represents the number of enriched genes associated with each GO term. Dots are color-coded according to their P values (adjusted by the Benjamini-Hochberg method). (B) GO biological process (left) and molecular function (right) gene set enrichment analysis in RVFV-infected spleen tissues. Gene sets with positive normalized enrichment scores are upregulated, whereas gene sets with negative normalized enrichment scores are downregulated. Ridges are color-coded according to their P values (adjusted by the Benjamini-Hochberg method). The cutoff for significance in all the analyses was set to an adjusted P value <0.05. The top significantly enriched gene sets altered in the spleen in response to RVFV infection at 4 days post-infection are presented in Fig. S5 in the supplemental material.