TABLE 2.

Incidence rates of dementia in MS and NMOSD patients.

	N	Events	Person-years	Incidence rate*	aHR† (95% CI)
Any dementia
Control	6,735	238	32,339.00	7.36	1 (Ref.)
MS	1,347	101	5,911.85	17.08	2.34 (1.84–2.96)
AD
Control	6,735	195	32,339.00	6.03	1 (Ref.)
MS	1,347	78	5,911.85	13.19	2.23 (1.70–2.91)
Vascular dementia
Control	6,735	22	32,339.00	0.68	1 (Ref.)
MS	1,347	15	5911.85	2.54	3.75 (1.91–7.35)
Any dementia
Control	7,300	145	31,812.73	4.56	1 (Ref.)
NMOSD	1,460	55	6,084.29	9.04	2.19 (1.61–3.00)
AD
Control	7,300	113	31,812.73	3.55	1 (Ref.)
NMOSD	1,460	38	6,084.29	6.25	1.99 (1.38–2.88)
Vascular dementia
Control	7,300	17	31,812.73	0.53	1 (Ref.)
NMOSD	1,460	10	6,084.29	1.64	3.21 (1.47–7.02)

N, number; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder; AD, Alzheimer’s disease; aHR, adjusted hazard ratio; CI, confidence interval.

*Incidence rates of 1,000 person-years.

^†Adjusted for age, sex, income, and the presence of diabetes, hypertension, or dyslipidemia.