TABLE 3.

Difference in the incidence of dementia between MS and NMOSD patients.

Type of dementia	Disease	N	Event	Person-years	Incidence rate*	aHR† (95% CI)
Any dementia	MS	1,347	101	5,911.85	17.08	1 (Ref.)
	NMOSD	1,460	55	6,084.29	9.04	0.67 (0.47–0.94)
AD	MS	1,347	78	5,911.85	13.19	1 (Ref.)
	NMOSD	1,460	38	6,084.29	6.25	0.62 (0.41–0.93)
Vascular dementia	MS	1,347	15	5,911.85	2.54	1 (Ref.)
	NMOSD	1,460	10	6,084.29	1.64	0.73 (0.32–1.69)

N, number; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder; aHR, adjusted hazard ratio; AD, Alzheimer’s disease; CI, confidence interval.

*Incidence rates of 1,000 person-years.

^†Matched for age, sex, income, and the presence of diabetes, hypertension, or dyslipidemia.