TABLE 2.
Mechanism of amphibian-derived wound-healing-promoting peptides.
| Peptide | Effector cell type | Signaling pathway | ||||||
|---|---|---|---|---|---|---|---|---|
| Immunocyte | Keratinocyte | Fibroblast | ||||||
| Recruitment | Cytokine | Proliferation | Migration | Proliferation | Migration | Differentiation | ||
| AH90 | / | + | - | + | / | / | + | MAPK, NF-κB, Smad |
| CW49 | + | + | / | / | / | / | / | HIF-1, eNOS and iNOS |
| Temporins A and B | + | / | + | + | / | / | / | / |
| Esculentin1a(1-21)NH2 | / | / | - | + | / | / | / | STAT3 |
| Tiger17 | + | + | + | + | + | / | + | MAPK, Smad |
| MSI-1 | / | + | / | + | / | / | / | / |
| Cathelicidin-OA1 | + | + | + | - | - | + | / | / |
| Cathelicidin-NV | / | + | + | + | + | / | + | MAPK |
| Antioxidin-NV | / | + | / | / | / | / | + | TLR4/p38/JNK/NF-κB, TGF-β1/Smad2 |
| Cathelicidin-DM | + | / | + | + | + | + | + | MAPKs |
| OM-LV20 | / | / | + | + | - | + | / | / |
| OA-GL21 | / | / | - | + | - | + | / | / |
| OA-GL17 | / | / | + | + | / | / | / | miR-663a/TGF-β1/Smad axis |
| Brevinin-2Ta | / | + | / | / | / | / | / | / |
| Brevinin-2PN | / | / | / | / | / | + | / | / |
| Pse-T2 | / | + | / | / | / | / | / | / |
| Tylotoin | + | + | + | + | + | / | + | MAPK, Smad |
| TK-CATH | / | + | + | + | / | / | / | MAPK |
| Ot-WHP | + | + | + | + | + | / | + | MAPKs, NF-κB, Smad |
| Bv8-AJ | / | + | + | / | + | / | / | IL-1/MAPK |
| DMS-PS2 | / | / | / | / | / | / | / | / |
| RL-10 | / | / | + | + | / | / | / | / |
| RL-QN15 | / | + | + | + | / | / | / | MAPK, Smad |
| FW-1/FW-2 | / | + | / | / | / | / | / | MAPK, NF-κB |
| PM-7 | / | / | / | / | + | + | / | MAPK |
/, no mentioned; -, had no effect; +, had positive effect.