TABLE 3.

Statistical Analyses of the Natural Log-Transformed Exposure of Multiple Doses of ER and IR Lorazepam in Study 1

Study 1: Once-Daily ER Lorazepam Compared With IR Lorazepam TID
PK Parameter, Natural Log-Transformed Exposure	ER Lorazepam* QD (n = 43) Geometric Mean	IR Lorazepam* q8h (n = 43) Geometric Mean	Geometric Mean Ratio ER/IR, %	90% CI
C max,SS	33.8	38.9	86.9	84.6–89.2
C min	23.2	27.2	85.3	82.2–88.5
AUCTAU,SS	661	730	90.6	88.4–92.8

*ER lorazepam administered as 3-mg dose QD; IR lorazepam as 1-mg dose q8h.