. 2023 Jun 19;43(4):350–360. doi: 10.1097/JCP.0000000000001715

TABLE 5.

PK Parameters of Once-Daily ER Lorazepam (4 mg) Administered in Fasted and Fed Conditions (Study 2)

PK Parameter, Mean (SD) Unless Otherwise Noted	Once-Daily ER Lorazepam (4 mg)
PK Parameter, Mean (SD) Unless Otherwise Noted	Fasted (n = 27)	Fed (n = 28)
T_max, median (range), h	10.0 (6.0–24.2)	12.0 (8.0–24.0)
T_lag, h	0.0 (0.0)	0.1 (0.5)
C_max, ng/mL	19.2 (5.1)	19.6 (3.2)
AUC_0–24, h × ng/mL	354 (92.5)	324 (54.0)
AUC_inf, h × ng/mL	937 (386.7)*	895 (329.6)
t_1/2, h	17.6 (6.7)*	17.4 (6.6)
CL/F, L/h	5.0 (2.2)*	5.1 (1.9)

*n for these values was 26.