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. 2023 Jun 29;220(9):e20221939. doi: 10.1084/jem.20221939

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© 2023 Chancellor et al.

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Figure S1. — Reactivity and function of self-reactive MAIT cell lines. (A) Expression of MR1 on cell lines used in this study. In the condition with 5-OP-RU, a 6-h incubation time was used. (B) Activation of self-reactive MAIT cells after proliferation with the indicated conditions from six individual donors. (C) Percentage of MR1-5-OP-RU tetramer+ cells within MAIT cells proliferating (CTV dull) and not (CTV bright) after stimulation with A375b-MR1 cells. (D) IFN-γ release by MAIT cells in the cultures illustrated in A (black bars) + aMR1 mAb (white bars). Concentrations are expressed as mean +SD. Data obtained from two donors. (E) Frequency of MAIT cells that secrete combination of the indicated cytokines.