Table 1. Influence of antineoplastic chemotherapy agents on fertility pattern.

Author	Age	Tumor type	Treatment	Antineoplastic agent	Effect	Number of patients
Gini et al (2019) 22	16–50 years old	Hodgkin Lymphoma Non-Hodgkin Lymphoma	Chemotherapy + Radiotherapy	Etoposide Doxorubicin Cyclophosphamide Vincristine Prednisone Bleomycin	↑ Amenorrhea	97
Shandley et al (2018) 23	20–35 years old	Breast Cancer Lymphomas Reproductive Tumor	Chemotherapy	—	↓ AFC ↓AMH	1090
Sinha et al (2018) 24	24–43 years old	Breast Cancer	Chemotherapy	Taxotere Cyclophosphamide Carboplatin Fluorouracil Epirubicin	↓ AFC	88
Al-Rawi et al (2018) 25	25–45 years old	Breast Cancer	Chemotherapy	Anthracycline Cyclophosphamide	↓AMH ↓E 2 ↑ LH	58
Anderson et al (2018) 26	18–45 years old	Hodgkin Lymphoma	Chemotherapy	—	↓AMH ↓E 2 ↑ FSH	67
D'Avila et al (2017) 27	27–40 years old	Breast Cancer	Chemotherapy	Cyclophosphamide	↑ Amenorrhea ↑ FSH ↓AMH ↓ AFC ↑E 2	49
Chang et al (2017) 28	15–51 years old	Chronic Myeloid Leukemia	Chemotherapy	Imatinib	↓ ejaculated volume ↓Sperm ↓ seminal density ↓ Viability Sperm	48
Creux et al (2017) 29	16–40 years old	Breast Cancer Cervical Cancer Hematological Cancer Gynecological Cancer Sarcoma Gastrointestinal Cancer	Chemotherapy	—	IVM - (normality)	164
Wenners et al (2017) 30	28–46 years old	Breast Cancer	Chemotherapy	Docetaxel Doxorubicin Fluorouracil Cyclophosphamide Epirubicin Paclitaxel Anthracycline	↓ ACF ↓AMH ↑ FSH ↑ LH	51
Perdrix et al (2017) 31	11–35 years old	Breast Cancer	Chemotherapy + Radiotherapy	Fluorouracil Epirubicin Cyclophosphamide Docetaxel	↓AMH	5775
McLaughlin et al (2017) 32	12–30 years old	Hodgkin Lymphoma	Chemotherapy	Adriamicina Bleomycin Vinblastine Dacarbazine Vincristine Etoposide Prednisone Doxorubicin Cyclophosphamide	↓ Follicular density ↓ Follicular development	13
Abir et al (2016) 33	5–18 years old	Medulloblastoma Acute Myeloid Leukemia Rhabdomyosarcoma Ewing Sarcoma Hodgkin Lymphoma Osteosarcoma	Chemotherapy	—	↑ Number of atretic follicles ↓ Oocyte maturation	20
Hamy et al (2016) 34	26–43 years old	Breast Cancer	Chemotherapy	—	↓AMH	134
Paoli et al (2016) 35	13–51 years old	Hodgkin Lymphoma	Chemotherapy	Doxorubicin Bleomycin Vinblastine Dacarbazine	↓Sperm ↑ Sperm anomalies	810
Even-Or et al (2016) 36	13 -36 years old	Acute Myeloid Leukemia	Chemotherapy	Melfalano	↓AMH ↓ LH ↓FSH	35
Jacobson et al (2016) 37	20–35 years old	Breast Cancer Acute Myeloid Leukemia Non Hodgkin Lymphoma	Chemotherapy + Radiotherapy	—	↑ Amenorrhea	1282
Gupta et al (2016) 38	11–18 years old	Osteosarcoma Hodgkin Lymphoma B cell Lymphoma Dysgerminoma Osteosarcoma	Chemotherapy	Cyclophosphamide Doxorubicin Cisplatine	↓AMH	17
Ruddy et al (2015) 39	40–45 years old	Breast Cancer	Chemotherapy	Trastuzumab Paclitaxel	↑ Amenorrhea	410
Huser et al (2015) 40	18–40 years old	Hodgkin Lymphoma	Chemotherapy	Adriamycin Bleomycin Vinblastine Vincristine Procarbazine Prednisone Etoposide Doxorubicin Cyclophosphamide	↑ FSH	108
Levi et al (2015) 41	20–44 years old	Colon Cancer Esophageal Cancer Thymic Cancer Rectal Cancer Neck Cancer	Chemotherapy	Cisplatine Capecitabine Fluoropyrimidine	↑ FSH ↓Inhibin B ↑ AMH	20
Thomas-Teinturier et al (2015) 42	18–39 years old	Bone Sarcoma Soft Tissue Sarcoma Neuroblastoma Hodgkin Lymphoma Non Hodgkin Lymphoma Acute Lymphoid Leukemia	Chemotherapy + Radiotherapy	Cyclophosphamide Ifosfamide Procarbazine busulfan	↑ FSH ↓AMH	105
Meissner et al (2015) 43	18–40 years old	Non Hodgkin Lymphoma	Chemotherapy	Cyclophosphamide Doxorubicin Vincristine Prednisone	↑ Amenorrhea ↓AMH	46

Abbreviations: AFC, antral follicle count; AMH, anti-mullerian hormone; E ₂ , estradiol; FSH, follicle stimulating hormone; IVM, in vitro maturation; LH, luteinizing hormone.