Table 2. Influence of radiotherapy + antineoplastic chemotherapy agents on fertility pattern.

Author	Age	Tumor type	Treatment	Corporal site	Dosage	Effect	Number of patients
Duhil de Bénazé et al (2018) 44	7–18 years old	Dysgerminoma	Chemotherapy + Radiotherapy	Lymphatic chains	20 Gy	↑ HcG	48
Fernandez-Pineda et al (2018) 45	4–22 years old	Hodgkin Lymphoma	Chemotherapy + Radiotherapy	Pelvic	9–55 Gy	↑ POF	127
Rives et al (2017) 46	24–43 years old	Testicular Cancer	Chemotherapy + Radiotherapy	Lymphatic chains	25 Gy	↓Sperm ↓ Sperm motility	54
Green et al (2017) 47	0–15 years old	Acute Lymphoid Leukemia	Chemotherapy + Radiotherapy	Testicular Hypothalamic Pituitary	40 Gy	↓Sperm ↓ Sperm motility ↓LH ↓FSH	171
Chemaitilly et al (2017) 48	18–45 years old	Leukemia Lymphoma Central Nervous System Tumors Embryonic Tumors Bone Tissue Sarcoma Carcinomas	Chemotherapy + Radiotherapy	Pelvic Lumbar region Sacral Entire Spine Abdominal flank Para-aortic Iliac Bladder Vaginal Lymphoid	30 Gy	↑ POF	988
Chow et al (2016) 49	5–20 years old	Leukemia Central Nervous System Tumors Lymphoma Renal tumor Neuroblastoma Soft Tissue Tumor Bone tumor	Chemotherapy + Radiotherapy	Neck Chest Legs Arms	—	↑ Sterility rate	10938
Boltežar et al (2016) 50	18–40 years old	Hodgkin Lymphoma	Chemotherapy + Radiotherapy	Pelvic	24 Gy	↑ Amenorrhea	131
Sonigo et al (2016) 51	17–33 years old	Hodgkin Lymphoma Breast Cancer	Chemotherapy + Radiotherapy	Subdiaphragmatic	> 26 Gy	↓IVM	22

Abbreviations: FSH, follicle atimulating hormone; HcG, human chorionic gonadotropin; IVM, in vitro maturation; LH, luteinizing hormone; POF, premature ovarian failure.