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. 2023 Mar 30;7:e2200463. doi: 10.1200/PO.22.00463

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FIG A1. — The results of MMR protein expression by immunohistochemistry and MMR gene mutations by NGS. (A) A total of 218 patients were confirmed as dMMR by immunohistochemistry, and 191 patients were confirmed as MSI by PCR or NGS. Specifically, 86 GEJ/GC patients and 108 CRC patients were confirmed as dMMR by immunohistochemistry. (B) The co-expression of MLH1/PMS2 loss was the most common pattern in both GEJ/GC and CRC. Besides, among 88 patients with the results of NGS, (C) nine patients were found to carry germline MMR gene mutations, and (D) 43 patients were found to carry somatic MMR gene mutations (D). *These patients lacked detailed information on PMS2 gene. GEJ, gastroesophageal junction; MSI, microsatellite instability; NA, not available; NGS, next-generation sequencing; PCR, polymerase chain reaction.