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Schematic overview of clonal expansion of HSCs in CH and the associated clinical consequences of circulating CH-mutant HSC clones. After somatic mutations in a driver gene, the selective advantage created allows the HSC clone to expand in the bone marrow and become overrepresented in the blood, contributing to inflammation and age-related disease while posing a risk of malignant transformation. Created with BioRender.4 CH, clonal hematopoiesis; HSCs, hematopoietic stem cells.
