TABLE 5.
Comorbidities for which effect modification was observed in female vs male subjects stratified by age at follow-up of 5-years.
| Comorbidity | Prevalence in S1 (%) | Prevalence in S2 (%) | OR1 [CI] | OR2 [CI] | p BDTT | p 1 | p 2 | ||
| F | M | F | M | ||||||
| Depression | 13 | 10 | 7 | 29 | 1.34 [0.56–3.23] | 0.18 [0.08–0.44] | 0.001 | 0.66 | 7.4e-5 |
| Chronic pain | 24 | 10 | 15 | 20 | 2.84 [1.28–6.31] | 0.71 [0.34–1.47] | 0.01 | 0.01 | 0.46 |
| Sleep disorder | 9 | 9 | 0 | 9 | 1 [0.38–2.6] | 0 | 8e-3 | 1 | 0.003 |
| Osteoarthritis | 15 | 6 | 0 | 2 | 2.76 [1.03–7.45] | 0 | 0.036 | 0.06 | 0.5 |
S1 represents stratum 1 (age at follow-up of 5 years > 50 years), S2 represents stratum 2 (age at follow-up of 5 years <= 50 years), OR1 and OR2 represent the odds ratio of female vs male subjects in S1 and S2 respectively, pBDTT represents the p-value obtained using the Breslow-Day-Tarone test (BDTT), p1 and p2 represents the p-value of odds ratio in S1 and S2 respectively obtained using Fishers-Exact test. F, female; M, male; CI, confidence interval.