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. 2023 Jun 29;18(6):e0285804. doi: 10.1371/journal.pone.0285804

Fig 3. Differential expression of mRNA transcripts in vaginal melanoma.

Fig 3

Differentially expressed mRNA transcripts in vaginal melanoma relative to normal vaginal mucosa. (A) Volcano plot of differentially expressed mRNAs in formalin fixed, paraffin embedded tissue from vaginal melanoma relative to paired normal vaginal mucosa, determined by NanoString (n = 3 each, minimum 2-fold change, p-value<0.01). Genes with differential expression between groups deemed significant are displayed in red according to the log2 of the fold change in expression (x) and log10 of the p-value (y). Genes in black demonstrated non-significant differential expression between groups. (B) Canonical pathway enrichment for differentially expressed mRNA transcripts in vaginal melanoma (identified using Ingenuity Pathway Analysis). Included pathways are those found to be significantly enriched based on -log(p) >1.3.