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. 2023 Jun 29;18(6):e0285804. doi: 10.1371/journal.pone.0285804

Fig 5. Differentially expressed genes are targets of multiple dysregulated miRs and hold negative correlations in expression across vaginal melanoma tissue samples.

Fig 5

(A, B) microRNA-gene target interaction networks demonstrate which differentially expressed genes in vaginal melanoma are common validated target genes for two or more differentially expressed microRNAs in vaginal melanoma. (A) mRNA transcripts with significantly increased expression have inverse relative expression patterns with two or more downregulated miRs in vaginal melanoma relative to normal vaginal mucosa. (B) mRNA transcripts with significantly decreased expression have inverse relative expression patterns with two or more upregulated miRs in vaginal melanoma relative to normal vaginal mucosa. (C) Heat map depicting Pearson correlation coefficient (-1 to 1) for each miR-mRNA pair, determined based on expression in individual tumor samples of each significantly dysregulated microRNA relative to each differentially expressed mRNA in vaginal melanoma (p<0.05). (D) Correlations between miRs and mRNAs demonstrate miR-mRNA pairs with evidence of an inverse correlation in expression in vaginal melanoma tissue (0.064<p<0.093).