Table 4. Differentially expressed microRNAs in vulvar melanoma relative to normal vaginal mucosa.
| microRNA | log2(fold change) | P-value | microRNA | log2(fold change) | P-value | microRNA | log2(fold change) | P-value | microRNA | log2(fold change) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| hsa-miR-1972 | -8.6151 | 4.74E-21 | hsa-let-7c-5p | -3.0046 | 0.000021 | hsa-miR-146a-5p | 5.5495 | 3.37E-10 | hsa-miR-148b-3p | 1.6038 | 0.000040 |
| hsa-miR-548z+hsa-miR-548h-3p | -5.6224 | 1.99E-15 | hsa-miR-23b-3p | -2.9235 | 0.000003 | hsa-miR-106a-5p+hsa-miR-17-5p | 3.5785 | 1.85E-08 | hsa-miR-296-5p | 1.4570 | 0.002838 |
| hsa-miR-1469 | -5.6208 | 2.72E-09 | hsa-miR-563 | -2.7474 | 2.25E-07 | hsa-miR-93-5p | 3.4985 | 1.03E-07 | hsa-miR-98-5p | 1.4243 | 0.009738 |
| hsa-miR-574-5p | -5.5027 | 4.31E-15 | hsa-miR-1260a | -2.6557 | 6.96E-08 | hsa-miR-30b-5p | 3.2907 | 1.47E-08 | hsa-miR-660-5p | 1.3631 | 0.000657 |
| hsa-miR-4488 | -5.4177 | 3.28E-09 | hsa-miR-522-3p | -2.5242 | 0.000857 | hsa-miR-25-3p | 2.9779 | 1.48E-06 | hsa-miR-30c-5p | 1.3151 | 0.001138 |
| hsa-miR-1285-5p | -5.2787 | 1.42E-13 | hsa-let-7b-5p | -2.4131 | 0.000070 | hsa-miR-15b-5p | 2.9254 | 1.29E-06 | hsa-miR-185-5p | 1.3053 | 0.000997 |
| hsa-miR-320e | -5.2216 | 7.44E-14 | hsa-miR-664a-3p | -2.3374 | 0.000009 | hsa-miR-19b-3p | 2.6536 | 1.17E-06 | hsa-miR-19a-3p | 1.2479 | 0.003557 |
| hsa-miR-4516 | -5.0055 | 3.82E-14 | hsa-miR-598-3p | -2.3270 | 0.000007 | hsa-miR-106b-5p | 2.5837 | 3.35E-06 | hsa-miR-454-3p | 1.2097 | 0.000178 |
| hsa-miR-6721-5p | -4.9247 | 5.43E-13 | hsa-miR-607 | -2.3005 | 1.14E-06 | hsa-miR-221-3p | 2.4664 | 0.000023 | hsa-miR-362-5p | 1.0113 | 0.002949 |
| hsa-miR-1915-3p | -4.6041 | 1.13E-10 | hsa-miR-3195 | -2.2827 | 0.000072 | hsa-miR-15a-5p | 2.4102 | 0.000282 | hsa-miR-132-3p | 1.0024 | 0.007256 |
| hsa-miR-4532 | -4.2900 | 1.26E-08 | hsa-miR-518b | -2.2301 | 0.000000 | hsa-miR-140-5p | 2.3663 | 0.000016 | |||
| hsa-miR-873-3p | -4.1482 | 1.20E-11 | hsa-miR-575 | -2.1817 | 0.000432 | hsa-miR-24-3p | 2.1969 | 0.000011 | |||
| hsa-miR-888-5p | -4.1126 | 1.87E-11 | hsa-miR-199a-3p+hsa-miR-199b-5p | -2.1393 | 0.001484 | hsa-miR-20a-5p+hsa-miR-20b-5p | 2.1708 | 0.000295 | |||
| hsa-miR-630 | -4.0812 | 2.44E-09 | hsa-miR-4454+hsa-miR-7975 | -2.0498 | 2.19E-09 | hsa-miR-181a-5p | 2.1586 | 0.000733 | |||
| hsa-miR-1290 | -4.0681 | 1.58E-10 | hsa-miR-411-5p | -2.0135 | 3.31E-08 | hsa-miR-340-5p | 2.1289 | 0.000034 | |||
| hsa-miR-548al | -3.8998 | 8.43E-12 | hsa-miR-1268b | -2.0096 | 1.08E-06 | hsa-miR-125a-5p | 1.9833 | 0.000792 | |||
| hsa-miR-548v | -3.7602 | 1.14E-13 | hsa-miR-126-3p | -1.8380 | 0.001915 | hsa-miR-191-5p | 1.8805 | 0.002468 | |||
| hsa-miR-363-3p | -3.6620 | 0.000126 | hsa-miR-183-5p | -1.8168 | 0.000017 | hsa-miR-361-5p | 1.8298 | 0.000637 | |||
| hsa-miR-145-5p | -3.5159 | 0.000460 | hsa-miR-23a-3p | -1.6851 | 0.001141 | hsa-miR-30d-5p | 1.7439 | 0.009307 | |||
| hsa-miR-877-5p | -3.3013 | 1.56E-07 | hsa-miR-612 | -1.5724 | 0.000753 | hsa-miR-324-5p | 1.7157 | 0.000168 | |||
| hsa-miR-125b-5p | -3.1873 | 0.000023 | hsa-miR-4443 | -1.4558 | 0.003660 | hsa-miR-374b-5p | 1.6828 | 0.000209 | |||
| hsa-miR-99a-5p | -3.0947 | 0.000060 | hsa-miR-107 | -1.4045 | 0.001186 | hsa-miR-9-5p | 1.6631 | 0.005784 | |||
| hsa-miR-551a | -3.0062 | 2.59E-10 | hsa-miR-378i | 1.6496 | 0.000036 |
Differentially expressed microRNAs in vulvar melanoma relative to normal vaginal mucosa. microRNAs that were also identified when vulvar melanoma was compared to primary cutaneous melanoma are bolded.