Table 6. Significantly enriched cellular and molecular functions for differentially expressed genes in vaginal melanoma.
| Functional Annotation Category | Minimum p-value | Associated Differentially Expressed Genes |
|---|---|---|
| Cellular Development | 3.02E-02 | DCN, ERBB3, FOS, FOXM1, GREM1, KIT, MLANA, SOCS3 |
| Cellular Growth and Proliferation | 3.02E-02 | DCN, ERBB3, FOS, FOXM1, GREM1, KIT, MLANA, NME1, SOCS3, TOP2A |
| DNA Replication, Recombination, and Repair | 2.33E-02 | FOS,FOXM1,MCM4,NME1,TOP2A, TPX2 |
| Cell Cycle | 3.22E-02 | DCN,ERBB3,FOS,FOXM1,KIT,MCM4, MYL9, NME1, TOP2A, TPX2 |
| Cellular Movement | 3.49E-02 | CCL19, ERBB3, FOS, FOXM1, KIT, MYL9, NME1, SOCS3, TOP2A |
| Cellular Assembly and Organization | 2.33E-02 | DCN, FOXM1, GREM1, MCM4, MLANA, TOP2A, TPX2 |
| Cellular Function and Maintenance | 2.25E-02 | CCL19,DCN,FOS,GREM1,KIT, MLANA,SOCS3,TPX2 |
| Cell-To-Cell Signaling and Interaction | 2.88E-02 | CCL19, DCN, ERBB3, FOS, FOXM1, KIT, MLANA, NME1, SLC7A5, TOP2A |
| Amino Acid Metabolism | 2.25E-02 | SLC7A5 |
| Antigen Presentation | 2.25E-02 | DCN |
| Carbohydrate Metabolism | 2.25E-02 | DCN, KIT, MLANA |
| Cell Death and Survival | 2.76E-02 | ERBB3, FOS, KIT, MLANA, NME1, TOP2A |
| Cell Morphology | 2.33E-02 | CCL19, ERBB3, FOXM1, KIT, MLANA, TPX2 |
| Cellular Compromise | 2.25E-02 | DCN, KIT, SLC7A5, TOP2A |
| Drug Metabolism | 2.25E-02 | KIT, SLC7A5 |
| Energy Production | 2.25E-02 | NME1 |
| Gene Expression | 2.76E-02 | FOS, NME1 |
| Lipid Metabolism | 2.25E-02 | KIT, MLANA |
| Molecular Transport | 2.25E-02 | MLANA, NME1, SLC7A5 |
| Nucleic Acid Metabolism | 2.25E-02 | NME1 |
| Small Molecule Biochemistry | 2.25E-02 | DCN, KIT, MLANA, NME1, SLC7A5 |