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. 2023 Jun 29;18(6):e0285804. doi: 10.1371/journal.pone.0285804

Table 8. Significantly enriched cellular and molecular functions for differentially expressed genes in vulvar melanoma.

Functional Annotation Category Minimum p-value Associated Differentially Expressed Genes
Cell Cycle 4.48E-02 ARG1, AURKA, AURKB, AXL, BIRC5, BLM, BRIP1, BUB1, BUB1B, CCNB1, CCNB2, CCNE1, CD40LG, CDC25A, CDCA5, CDK1, CDKN1A, CHEK2, CLSPN, DCN, DTL, E2F1, EGFR, EME1, EXO1, FEN1, FGFR2, FLT3, HJURP, KIF20A, KIF2C, KPNA2, LMNB1, MCM4, NME1, NUF2, PCLAF, PDGFRA, PLK1, PTCH2, RFC3, SERPINB5, TOP2A, TPX2, UBE2C, XRCC2
Cellular Assembly and Organization 3.78E-02 AURKA, AURKB, BIRC5, BLM, BUB1, BUB1B, CCNB1, CCNB2, CCNE1, CDK1, CDKN1A, CHEK2, CLSPN, DCN, EGFR, EME1, EXO1, FEN1, GTSE1, HJURP, KIF20A, KIF2C, LMNB1, LOX, NUF2, PLK1, TIMELESS, TOP2A, TPX2, XRCC2
DNA Replication, Recombination, and Repair 4.91E-02 AURKA, AURKB, BIRC5, BLM, BRIP1, BUB1, BUB1B, CACYBP, CCNB1, CCNB2, CCNE1, CDC25A, CDCA5, CDK1, CDKN1A, CHEK2, CLSPN, DTL, E2F1, EGFR, EME1, EXO1, FEN1, FGFR2, GTSE1, HJURP, KIF20A, KIF2C, KPNA2, LMNB1, MCM4, NT5E, NUF2, PCLAF, PLK1, RFC3, RRM2, SMO, TIMELESS, TOP2A, TPX2, UBE2T, XRCC2
Cell Morphology 4.14E-02 AURKA, AURKB, BIRC5, BLM, BRIP1, BUB1, CDK1, CDKN1A, CHEK2, CPA3, DCN, E2F1, EGFR, EXO1, FEN1, HDC, JAG1, KIF20A, KIF2C, KPNA2, LOX, NUF2, PLK1, PTGER4, SERPINB5, SMO, TPX2, UBE2C
Cellular Movement 3.78E-02 AURKA, AURKB, BIRC5, CCL19, CCNB1, CCR4, CD40LG, CDK1, CDKN1A, EGFR, KIF20A, NME1, PLK1, TOP2A, UBE2C
Cellular Development 3.78E-02 AXL, BIRC5, CDK1, CDKN1A, CHEK2, E2F1, EGFR, FGFR2, JAG1, LMNB1, LOX, MUC1, PDGFRA, PLK1, SMO, UBE2C
Cellular Growth and Proliferation 3.78E-02 AXL, BIRC5, CCNE1, CDK1, CDKN1A, CHEK2, E2F1, EGFR, FGFR2, FLT3, LMNB1, LOX, MUC1, PDGFRA, PLK1, TIMELESS, UBE2C
Cell Death and Survival 4.10E-02 BIRC5, CDKN1A, DCN, E2F1, EGFR, FGFR2, JAG1, SERPINB5, SMO
Cellular Function and Maintenance 4.14E-02 AURKA, AURKB, AXL, BLM, BRIP1, CCNB1, CCNE1, CDKN1A, E2F1, EGFR, EXO1, FEN1, FGFR2, GTSE1, JAG1, KIF2C, KPNA2, NME1, SMO, TIMELESS, TPX2
Amino Acid Metabolism 3.73E-02 ARG1, EGFR
Cell-To-Cell Signaling and Interaction 3.73E-02 CCNB1, CCNB2, EGFR, LAMA2
Cellular Compromise 2.06E-02 AURKA, AURKB, BLM, BRIP1, BUB1, CCNB1, CDC25A, CDK1, CDKN1A, CHEK2, EME1, EXO1, FEN1, GTSE1, XRCC2
Lipid Metabolism 3.73E-02 EGFR, FGFR2, HSD11B1, PTGER4
Molecular Transport 3.73E-02 ARG1, EGFR, FGFR2, HDC, HSD11B1, PTGER3, PTGER4
Small Molecule Biochemistry 3.73E-02 ARG1, EGFR, FGFR2, HSD11B1, NME1, PTGER4, RRM2
Vitamin and Mineral Metabolism 1.34E-02 EGFR, FGFR2
Nucleic Acid Metabolism 3.73E-02 NME1, RRM2
RNA Post-Transcriptional Modification 3.73E-02 NME1, RRM2