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. 2023 Jun 15;11:1184882. doi: 10.3389/fpubh.2023.1184882

Table 1.

Characteristics of the included studies.

No. References Country Study design Sample population Sample size Collection period Purpose of self-medication Prevalence of self-medication % Type of product used for self-medication
1 Khami et al. (12) Iran CS Dental visits 756 mid-4 2020 to mid-7 2020 Dental problem Before pandemic 26.5% After pandemic 56.1% Amoxicillin 22.7%, incomplete information 14.8%, azithromycin 4.7%, co-amoxiclav 3.8%, amoxicillin and metronidazole 3.5%, metronidazole 2.3%, penicillin 1.7%, cefixime 0.9%, doxycycline 0.9%, clindamycin 0.6%, and azithromycin and penicillin 0.3%
2 Lam et al. (31) China CS General people 632 2020.11.2–2020.12.18 Prevention of COVID-19 and others All 54.1% Before pandemic 48.4% During pandemic 44% Vitamins or other dietary supplements 25.3%, Chinese herbal medicine 19.3%, and Western herbal medicine 5.1%
3 d'Arqom et al. (32) Indonesia CS Mothers with school-age children 610 2020.7–2020.12 Prevention and/or treatment of COVID-19 NR Medication: Antibiotics 42%, antivirus 16%, antimalaria 5%, and others 37%; Vitamins: Vitamin C 39%, multivitamins and minerals 32%, vitamin E 11%, vitamin D 8%, Zinc 6%, and Selenium 1%; Herbs/Natural product: Ginger 31%, honey 30%, curcumin 22%, eucalyptus 5%, and other 12%.
4 Goodwin et al. (34) Thailand CS General people 1,000 2020.4.20–2020.5.3 Prevention of COVID-19 15.0% Vitamins or other medicines
5 Onchonga et al. (9) Kenya CS Healthcare workers 379 NR Treatment for specific symptoms Before pandemic 36.1% After pandemic 60.4% NR
6 Mahmoudi (27) Iran CS COVID-19 patients 436 2020.3.11–2020.10.13 Treatment of COVID-19 56.1% Antibiotics
7 Sarkar and Rajamani (35) India CS General people 200 2020.8–2020.11 Treatment for specific symptoms 65% Diclofenac and paracetamol
8 Arain et al. (42) Pakistan CS General people 698 2020.4–2020.9 Treatment for specific symptoms NR OTC, antibiotics, and others (sedatives)
9 Sadio et al. (74) Togo CS The healthcare, air transport, police, road transport and informal sectors 955 2020.4.23–2020.5.8 Prevention of COVID-19 34.2% Vitamin C 27.6%, traditional medicine 10.2%, chloroquine/hydroxychloroquine 2.0%, and azithromycin 1.2%.
10 Oktarlina et al. (33) Indonesia CS Medical faculty students 252 2020.1.1–2020.1.10 Treatment for specific symptoms NR Supplement and drugs
11 Coman et al. (59) Romania Mixed method (interview and survey) Interviews: five doctors with different specialties. Survey: predominantly adults and student 543 2021.1–2021.4 Prevention and treatment of COVID-19 NR Symptomatic medicines for allergies, respiratory, gastric, pain, anxiolytic antibiotics, vitamins, anti-thermics, oral disinfectants, antispasmodics, anti-diarrheals, and non-steroidal anti-inflammatory medication (ibuprofen, diclofenac, etc.)
12 Tossou (75) Togo CS Households 1,946 2020.7.8–2020.7.17 No specific indication 61.41% NR
13 Tandon et al. (36) India CS General people 312 NR Prevention of COVID-19 and others NR Prophylactic therapy with the perception to prevent COVID-19 infection (n = 4), VC (n = 2), hydroxychloroquine (n = 1).
14 Mansuri et al. (54) Saudi Arabia CS General people under lockdown 388 2020.3–2020.4 Prevention and treatment of COVID-19 Self-medication for fever 35.1% NR
15 Sen Tunc et al. (46) Turkey CS Parents who applied to dental clinic regarding their children's dental problems 389 2020.7–2020.10 Dental problem 70.2% (self-medicated their children) Analgesics 98%, antibiotics 38.1%, mouthwashes 13.1%, and herbal medicines 8.8%
16 Sikdar et al. (49) Bangladesh CS General people 2,941 2020.11.25–2020.12.4 Sleep disturbances 7.14% NR
17 Tekeba et al. (76) Ethiopia CS Community-pharmacy clients 416 2020.6.1–2020.6.30 Treatment for specific symptoms 73.6% Painkillers 83.7%, antibiotics 10.5%, cough syrup 1.6%, antacid 1.6%, oral contraceptive 1.3%, and other 1.3%
18 Soriano-Moreno et al. (65) Peru CS General people 3,610 2020.9.7–2020.9.21 Prevention and treatment of COVID-19 Prevention: 8% Treatment: 16.4% Chlorine dioxide
19 Merwid-Lad et al. (60) Poland CS The students during the academic year 2020/2021 624 2021.11.14–2021.12.23 Anxiety, depression, or sleeping problems and others 70% Dietary supplements: Magnesium or a combination of magnesium with vitamin B6, Melissa officinalis L. (melissa, lemon balm), melatonin, a Vitamin-B group complex, Valeriana officinalis L. root (valerian root), Matricaria recutita L. (wild chamomile), Withania somnifera L. (ashwagandha), Humulus lupulus L. (hop), cannabidiol (CBD) oil, ginseng, vitamin D with or without menaquinone-7 (MK7), vitamin C, vitamin B12, multivitamin preparations, zinc, iron, and omega-3 fatty acids OTC: Antihistamines, analgesic, antipyretic, and anti-inflammatory drugs
20 Yusuf and Sarkinfada (77) Nigeria CS Individuals that visited medical stores and medical store owners 332 NR Treatment for specific symptoms During pandemic 68.5% Before pandemic 64.2% Artemisinin combination therapy 39.5%, Co-trimoxazole 16.0%, amoxicillin 14.1%, ciprofloxacin 12.9%, ampicillin-cloxacillin 6.7%, tetracycline 6.7%, and chloroquine 3.7%
21 Bello et al. (78) Nigeria CS Nigerian undergraduates 356 2020.5–2020.8 Prevention and treatment of COVID-19 65.4% Vitamin C 52%, paracetamol/panadol 43%, herbs 28.7%, anti-malaria 24.7%, food supplements 15.7%, cough syrup 8.1%, slimming pills and teas 6.5%, piriton 3.4%, anti-diarrhea 2.2%, tramadol 2%, hydroxychloroquine 2%, and other 15.2%
22 Gupta and Chakraborty (37) India CS Adults with a history of taking allopathic medication in the last month 170 2020.8 Treatment for specific symptoms 57.7% Pain suppressor 46.9%, antibiotics 43.9%, anti-acidity 39.8%, and anti-allergics (including cough suppressants) 16.3%
23 Akintunde et al. (83) Sub-Saharan Africa CS General people 536 2020.8.18–2020.8.24 No specific indication 38.8% NR
24 Saleem et al. (43) Pakistan CS Undergraduate students 520 2020.3–2020.6 Treatment for specific symptoms 58.1% Analgesics 55.96%, antibiotic 38.74%, antipyretic 34.44%, antihistamine 20.86%, vitamins 17.55%, antiemetic 9.27%, antidiarrheal 8.28%, antacids 5.96%, laxatives 4.97%, food supplements 4.30%, and others 13.58%
25 Tobaiqi et al. (55) Saudi Arabia CS General people 281 2020.7–2020.9 Treatment for specific symptoms 58% Analgesics 42.9%, antibiotic 14.1%, herbs 13.5%, vitamins 9.2%, eye drops 6.1%, antacid 4.9%, roquia treatment 2.5%, laxatives 0.6%, and other 6.1%
26 Heshmatifar et al. (28) Iran CS Older adult>60 342 2020 Prevention of COVID-19 56.4% Pain reliever 52%, vitamins and supplements 47%, anti-cold 44%, sedative 42.6%, antibiotics 27.1%, gastrointestinal drugs 25.9%, and cardiac drugs 17%
27 Mulder et al. (61) Netherlands CS General people 1,004 2020.5.22–2020.5.27 Prevention and treatment of COVID-19 and others 59.4% Homeopathic remedies 10.2%, Bach flowers 4.1%, and Herbal medicine 19.0%: Echinacea, Passiflora, curcumin, red yeast rice (Xuezhikang), milk thistle (Silybum marianum), ashwagandha (Withania somnifera), cranberry, black cohosh, ginseng, and ginkgo biloba Vitamins/minerals 55.0%: Multivitamins, vitamin C, vitamin D, vitamin B, selenium, zinc, iron, magnesium, and calcium Other CM 14.0%: Omega 3, 6, 9, co-enzyme Q10, protein drink/shake, probiotics, and glucosamine-chondroitin-MSM
28 Elayeh et al. (57) Jordan CS General people 1,179 2020.3.26–2020.4.16. Prevention and treatment of COVID-19 80.4% Antibiotics: azithromycin and doxycycline; Analgesics and antipyretics: paracetamol, ibuprofen, and diclofenac; Minerals: zinc, magnesium, and iron salts; Vitamins: vitamins C, D, and B and multivitamins; Herbals and supplements: propolis, omega 3 fatty acids, and immune boosting supplements; Antithrombotic drugs: aspirin and enoxaparin; Cold and cough preparations; Antihistamines; Others: antiseptic lozenges, nasal solutions containing normal saline or sea water, clove oil, and menthol rub.
29 Chopra et al. (38) India CS General people with middle and high socioeconomic status 1,100 2020.5.1–2020.5.10 Anxiety 25% NSAIDS 36%, antiulcer drugs 18%, H1 Anti-histaminics, 15%, multivitamins 7%, antimicrobials 6%, herbal drugs 3%, and hydroxychloroquine 1%
30 Azhar et al. (56) Saudi Arabia CS General people 290 2020 Prevention of COVID-19 53% Allopathic medicines: Azithromycin 21.5%, cough syrup 16.7%, soften 15.6%, disprin 5.2%, ivermectin 3.3%, dexa methasone 3%, and hydroxychloroquine 2.6% Herbals: Sana makhi tea 32.6%, green tea 4.8%, homeopathic medicines 3.3%, lemon tea 2.4%, ginger tea 2%, joshanda tea 1.6%, and tootsiah syrup 0.4% Vitamins: Vitamin C 27%, surbex Z 18.9%, vitamin D 18.5%, Tab. calcium 14.8%, multi-vitamins 2%, centrum 0.4%, and folic acid 0.4%
31 Amuzie et al. (79) Nigeria CS General people 469 2021.10–2021.11 Prevention and treatment of COVID-19 30.3% Herbal products 43.7%, anti-malarials (ACTs) 34.5%, vitamin supplements 28.2%, azithromycin 23.9%, ivermectin 12.7%, analgesics 12%, calcium supplement 8.5%, hydroxychloroquine 8.5%, and ciprofloxacin 4.9%
32 Okoye et al. (80) Nigeria CS Health care professionals 669 2021.3–2021.4 Prevention and treatment of COVID-19 36.3% Ivermectin 9.5%, azithromycin 9.1%, vitamin C 7.4%, chloroquine 5.7%, and zinc sulfate 2.0%
33 Acharya et al. (58) Nepal CS Medical students and staffs 383 2021.11.1–2021.11.30 Prevention and treatment of COVID-19 50.4% Paracetamol 18.9%, vitamin C 18.6%, zinc 12.7%, multivitamins 11.1%, vitamin D 9.6%, azithromycin 8%, cough syrup 7.8%, ibuprofen 6.8%, calcium 3.2%, ivermectin 1.2%, montelukast 0.7%, dexamethasone 0.6%, chloroquine 0.3%, and other 0.4%
34 Gaviria-Mendoza et al. (68) Colombia CS General people 397 2020.6.30–2020.9.14 Prevention of COVID-19 and treatment for specific symptoms 34.3% Nervous system: Analgesics 86.0%, acetaminophen 85.3%, and other (psycholeptics and psychoanaleptics) 5.9% Musculoskeletal system: Anti-inflammatory and anti-rheumatic products 47.1%, muscle relaxants 3.7% Respiratory system: Antihistamines for systemic use 26.5%, cough and cold preparations 24.3% Alimentary tract and metabolism: Vitamins 21.3%, drugs for acid-related disorders 16.9%, and other (drugs for constipation, anti-diarrheals, etc) 6.6% Anti-infectives for systemic use: Anti-bacterials for systemic use 12.5%, anti-mycotics for systemic use 2.2% Blood and blood forming organs (antithrombotic agents) 13.2% Antiparasitic products, insecticides, and repellents: Antiprotozoals 3.7% and anthelmintics 2.9% Other: Systemic hormonal preparations 2.2%, cardiovascular system 1.5%, dermatologicals 0.7%, and other (natural products) 19.1%
35 Rafiq et al. (44) Pakistan CS General people 920 2020.3–2020.8 Treatment for specific symptoms Total 63.7% Among adults 67.3% Among teenagers 46.9% NR
36 Vasquez-Elera et al. (66) Peru CS Patients hospitalized in COVID-19 areas of the Cayetano Heredia Hospital who self-medicated before admission. 301 2020.5–2020.6 Treatment of COVID-19 54.8% Ivermectin 85.5%, azithromycin 71.5%, corticosteroids 46.7%, and NSAIDs 31.5%
37 Wegbom et al. (81) Nigeria CS General people 461 2020.6–2020.7 Prevention and treatment of COVID-19 41% Vitamin C and multivitamin 51.8%, other antimalarial drugs 47.1%, amoxicillin 24.9%, ciprofloxacin 14.6%, herbal products 10.2%, metronidazole 8.5%, erythromycin 5.3%, and hydroxychloroquine and chloroquine 3.2%
38 Quispe-Cañari et al. (67) Peru CS General people 3,792 2020.6.5–2020.6.17 Prevention and treatment of COVID-19 33.4% Acetaminophen 27%, ibuprofen 7.4%, azithromycin 4.8%, penicillin 2.3%, antiretrovirals 1.6%, and hydroxychloroquine 0.7%
39 Yasmin et al. (10) Pakistan CS Medical Students 489 2021.1.25–2021.2.20 Prevention and treatment of COVID-19 83% Paracetamol 65.2%, multivitamins 56.0%, ibuprofen 29.0%, cetirizine 27.8%, azithromycin 25.6%, hydroxychloroquine 8.8%, antivirals 7.2%, ivermectin 4.5%, doxycycline 3.9%, and others 11.4%
40 Zhang et al. (72) Australia CS General people 2,217 2020.3.16–2020.4.1 Prevention of COVID-19 19.5% Antibiotics
41 Makowska et al. (8) Poland CS General people 1,013 2020.6.8–2020.6.15 Prevention of COVID-19 and others 45.6% NR
42 Ceulemans et al. (62) Ireland, Norway, Switzerland, The Netherlands, and United Kingdom (UK) CS Pregnant and Breastfeeding Women 7,260 2020.6.16–2020.7.14 No specific indication Pregnant women: 22.0%
Breastfeeding women: 16%
Medications, folic acid, multivitamins, iron-containing preparations, omega-3 fatty acids, and other products (including but not limited to pre- and probiotics, herbal remedies and homeopathic products)
43 Alonso-Castro et al. (69) Mexico CS Population with symptoms associated with anxiety and depression 2,100 2020.3–2020.6 Anxiety and depression 61.9% Orange blossom (n = 524), chamomile (n = 508), valerian (n = 419), tilia (n = 360), passion flower (n = 353), cinnamon (n = 171), ginkgo (n = 153), toronjil (n = 134), hierba de San Juan (n = 110), aloysia citrodora (n = 90), and marijuana (n=44)
44 Karataş et al. (47) Turkey CS General people 389 2020.4.1–2020.4.30 Prevention of COVID-19 39.3% Herbal medicines 30.8% and nutritional supplements/vitamins 23.8%
45 Ruiz-Padilla et al. (70) Mexico CS General people 16,724 2020.3–2020.11 Prevention of COVID-19 35.3% Acetaminophen, aspirin, ibuprofen, dexamethasone, hydroxychloroquine, chloroquine, azithromycin. ivermectin, chlorine dioxide, transfer factor, green tea, zinc, vitamin C, lemon, curcuma, ginger, propolis, and ginseng
46 Ahmed et al. (50) Bangladesh CS General people 1,222 2020.6.27–2020.7.20 Prevention of COVID-19 and treatment for specific symptoms NR Allopathic medicines 15%: Arsenicum album 30.4%, vitamin supplements (vitamin C, D, B, and multivitamins) 27.1%, mineral supplements (mostly zinc) 19.9%, paracetamol 16.0%, antihista, mines (fexofenadine, desloratadine, and chlorpheniramine) 11.6%, antiasthmatics (mostly montelukast) 8.8%, and ivermectin 5.5%, Herbal 56.7%: Tea (normal and herbal) 70.9%, ginger 56.5%, black seed 32.8%, honey 30%, clove 28.8%, cinnamon 23.0%, garlic 16.9%, lemon 13.6%, black pepper 8.8%, cardamom 2.8%, bay leaf 2.1%, and tulsi 1.8%
47 Kristoffersen et al. (63) Norway, Sweden and the Netherlands CS General people 2,494 2020.4–2020.6 Prevention or treatment of COVID-19 and treatment of COVID-19 related symptoms 62.8% Herbs 18.2%: Ginger 6.8%, curcumin 5.8%, garlic 4.2%, green tea 4.0%, herbal tea 4.0%, cranberry 3.9%, blueberry/blueberry extract 3.5%, oregano 2.6%, echinacea 2.1%, aloe vera 2.0%, ginseng 1.8%, red yeast rice (xuezhikang) 1.8%, rhodiola rosea 1.0%, passiflora 0.7%, ginkgo biloba 0.6%, Indian ginseng 0.5%, actaea racemosa (black cohosh) 0.5%, chaga 0.3%, lady's thistle 0.2%, and Other herbs 3.1% Vitamins and minerals 49.9%: Vitamin D 21.2%, Multivitamins 17.5%, Vitamin C 15.7%, Magnesium 11.4%, Vitamin B 7.8%, Calcium 4.7%, Iron 4.2%, Zinc 2.7%, Selenium 1.1%, and Other vitamines and minerals 5.3% Homeopathic remedies 4.7% Bach flower remedies 2.3% Dietary supplements 29.2%: Omega 3, 6, or 9 including cod liver oil 22.2%, Protein shake 4.5%, Probiotic 3.1%, Glucosamine 1.9%, Q10 0.8%, and Other dietary supplements 2.5%
48 Mutua et al. (73) Kenya CS The pharmacy customers and the pharmacy workers 80 2020.6–2020.7 Treatment for specific symptoms 78% Anti-pyre-tics, NSAIDS, antibiotics, sedatives and hypnotics, nutritional supplements, and herbal/traditional medicines
49 Farooq et al. (39) India CS Dental students and interns 100 2021.9–2021.11 Treatment for specific symptoms 34.4% Acetaminophen 41.9%, combination of paracetamol, propyphezone & caffeine 18.3%, ibuprofen 14%, aspirin 8.6%, diclofenac 3.3%, mefenamic acid 3.2%, and ketoprofen 1.1%
50 MCPS and Malik (45) Pakistan CS Dental patients 451 2020.9.20–2020.12.5 Dental problem 86.25% Pain relievers 68.5%, antibiotics 35.5%, other 18.6%, and steroids 6.5%
51 Aitafo et al. (82) Nigeria CS Health workers 220 2021.1.2–2021.3.2 Prevention and treatment of COVID-19 15.9% Vitamin C 97.1%, zinc 80.0%, azithromycin 68.6%, anti-malarials (not hydroxychloroquine) 45.7%, hydrochloroquine/chloroquine 34.3%, multivitamins 31.4%, combination of antibiotics 14.3%, amoxicillin/clavulanic acid 8.6%, erythromycin 5.7%, amoxicillin 5.7%, ciprofloxacin 2.9%, and metronidazole/flagyl 2.9%
52 Ikiisik et al. (48) Turkey CS Older adult >65 390 2021.2.22–2021.3.19 Prevention of COVID-19 and treatment for specific symptoms 48.7% Analgesics 75%, anti-gribal 14%, antibiotics 5.7%, and vitamin 5.2%
53 Nasir et al. (51) Bangladesh CS General people 626 2020.4–2020.5 Prevention of COVID-19 and treatment for specific symptoms 88.33% Ivermectin 77.15%, azithromycin 54.15%, montelukast 43.13%, calcium supplements 41.37%, doxycycline 40.25%, hydroxychloroquine 20.44%, zinc 19.81%, and vit-d 13.58%
54 Alavi Namvar et al. (29) Iran CS Dental patients 306 2020.10–2021.4 Dental problem 53.9% Ibuprofen 23.6%, salt and water mouthwash 20.9%, amoxicillin 17.7%, acetaminophen 10.7%, metronidazole 2.9%, novafen 2.7%, mefenamic acid 1.9%, penicillin 0.3%, and others (herbs, garlic, onion, honey, lime juice, local analgesics, local salt, lidocaine, and Dentol) 19.3%
55 González-González et al. (71) Mexico CS University students 284 2021.2–2021.4 Prevention of COVID-19 20.4% Vitamins 53.9%, medicinal drugs 17.1%, herbal 10.5%, alcohol 6.6%, chlorine dioxide 3.9%, and others 7.9%
56 Chellappan et al. (40) India CS General people 478 2020.9.1–2020.11.30 Prevention of COVID-19 84.5% Home remedies 50.2%, Allopathy 46.3%: Vitamins and other dietary supplements 51.7%, medication to reduce fever 14.1%, antibiotics 12.1%, hydroxychloroquine 7.2%, painkillers 4.2%, ivermectin 3%, other medication 7%; homeopathy 32.2%, ayurveda 16.6%, naturopathy 4.5%, siddhi 3.5%, unani 0.5%, and other systems 0.2%
57 Likhar et al. (41) India CS Medical students 394 NR No specific indication 73.85% Allopathy 43.65%: antibiotics 53.04%, anti-pyrectics 17.25%, anti-fungal 3.29%, anti-malarial 0.2%, any other 30.20%; homeopathy 8.12%, ayurvedic 7.86%, mixed 11.42%
58 Sujan et al. (52) Bangladesh CS COVID-19 recovered patients 360 2020.9–2021.2 Prevention/treatment of COVID-19 11% Paracetamol 30.6%, herbal products/drugs 30%, and antibiotics 29.7%
59 Mir et al. (11) India CS General people 168 2021.5 Treatment of COVID-19-like symptoms 59.9% Paracetamol 85.0%, azithromycin 58.0%, cough syrup 30.0%, ivermectin 18.0%, doxycycline 16.0%, ibuprofen 13.0%, dexamethasone 7.0%, hydroxychloroquine 4.0%, famotidine 3.0%, penicillins 3.0%, remdisivir 2.0%, budesonide inhalations 1.0%, and others 19.0%
60 Gerbier et al. (64) Norway, Belgium, Switzerland, the Netherlands, and the United Kingdom CS Pregnant and postpartum women 5210 2021.6.10–2021.8.22 No specific indication Pregnant women: 18.0% Postpartum women: 22.5% Pregnant women: paracetamol 32.8%, alginic acid 5.2%, ordinary salt combinations as antacids (combinations of calcium, aluminum, and magnesium) 4.6%; Postpartum women: paracetamol 76.6%, ibuprofen 29.2%, and cetirizine 4.1%
61 Dehghan et al. (30) Iran CS General people 782 2020.4.20–2020.8.20 No specific indication 84% Medicinal herbs 48.8%: chamomile, thyme, ginger, mint, cinnamon, Imam Kazim medicine (a mixture of myrobalan, fennel, and brown sugar), hollyhocks, lavender, pennyroyal, buttercup, jujube, rosemary, viper's-buglosses, fennel, and a mixture of apple cider vinegar and honey Nutritional supplements 61.3%: vitamin D, vitamin C, multi-vitamin, and others, including vitamin B6, vitamin B complex, vitamin E, zinc, calcium, iron, omega-3, and folic acid, or a combination of supplement
62 Johora et al. (53) Bangladesh CS Medical Students 916 2020.10.1–2020.10.31 Prevention of COVID-19 and treatment for specific symptoms 51.6% Paracetamol 88.37%, anti-histamine 48.20%, vitamin C 39.96%, zinc 31.08%, ORS 20.51%, NSAIDs 20.30%, vitamin D 19.03%, vitamin E 15.01%, montelukast 14.16%, calcium 13.95%, anti-ulcerants 9.73%, sedatives 9.30%, anti-emetics 9.10%, bronchodilators 5.71%, antispasmodic 4.65%, antitussive 4.02%, herbal 3.17%, oxygen 0.63%, and others 5.50%

Abbreviations: CS, cross-sectional study; NR, not reported.