Fig. 4.

Structural constituent expression varies temporally for cases of PO (solid line) and LRT (dotted lines). For PO models, Collagen I and III content decreases at the start of inflammation (${\mathbf{A}}_{\mathit{I}\mathit{n}\mathit{f}}$), then increases drastically at the end of inflammation (${\mathbf{\Omega }}_{\mathit{I}\mathit{n}\mathit{f}}$). Collagen I and III both appear earlier in LRT models, but by the end of inflammation, the overall content is similar to PO (Connelly et al. 1985, 1992; Fang et al. 2007; Knowlton et al. 1992; Lerman et al. 1983). Collagen IV, an important component of the basement membrane, increases for both PO and LRT models, but this increase typically occurs sooner in LRT (Knowlton et al. 1992; Morishita et al. 1996). Fibronectin expression increases for both PO and LRT models. In LRT models, however, expression is shifted forward temporally (Carlyle et al. 1997; Knowlton et al. 1992). For PO, elastin is degraded while hyaluronan content increases (Petz et al. 2019; Rienks et al. 2014; Skjøt-Arkil et al. 2013; Waldenström et al. 1991; Yu et al. 2018). These constituents have not been well-studied and defined for cases of LRT. All axes rely on arbitrary units, and curves are qualitative representations of the studies summarized within this review. The start of inflammation (${\mathbf{A}}_{\mathit{I}\mathit{n}\mathit{f}}$) is defined as immediately following MI and before the application of LRT. The end of inflammation (${\mathbf{\Omega }}_{\mathit{I}\mathit{n}\mathit{f}}$) is defined by mass migration and proliferation of fibroblasts in the infarcted region