Fig. 5.

In rodent infarcts, LRT (2.5 h post-MI), reduced MMP-1, -2, and -9 activity. MMP activity occurring in non-reperfused (closed circles) and LRT (open circles) infarcts are compared at days 1, 2, 3, and 7 post-MI for MMP-1 (a) and MMP-2 (both unreduced form—62 kDa (b), and reduced form—65 kDa (c)) using zymography. No MMP-9 activity was detected in the control rodent myocardium, so MMP-9 activity is shown as a ratio of reperfused compared to non-reperfused infarct zones. Additionally, the absolute increase in MMP-9 activity for non-reperfused (closed circles) and reperfused (open circles) infarct zones is in the inset (d). Reprinted from J. Mol. Cell. Cardiol., Vol. 29, no. 9, W. C. Carlyle et al., “Delayed reperfusion alters matrix metalloproteinase activity and fibronectin mRNA expression in the infarct zone of the ligated rat heart,” pp. 2451–2463. Copyright (1997), with permission from Elsevier