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. 2023 Jun 29;8:96. doi: 10.1038/s41541-023-00691-1

Fig. 2. Serum viral neutralizing antibody titers in aged vs. young, immunized mice.

Fig. 2

Neutralizing antibody titers measured in sera from mice immunized three times IN with 10 or 20 μg RBD with PBS, NE, or NE/IVT, or IM with RBD with Addavax using lentivirus PSVs expressing SARS-CoV-2 S protein derived from (a) WT, b B.1.617.2, c B.1.351, d B.1.1.529 viral variants. Titers are shown as mean ± SEM (n = 5/grp) (*p < 0.05, **p < 0.01 by Mann–Whitney U test shown only for NE/IVT/10 RBD compared to other treatments in the same age group, and for NE/IVT/20 RBD compared only to high dose RBD groups within the young group. Full statistical analysis is shown in Supplementary Table 1).