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. 2023 Jan 25;44(7):1391–1403. doi: 10.1038/s41401-022-01037-8

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — a ALT, b AST, c TBIL (n = 6, 7, 6, 6, 4, 5, 4, respectively) in serum of mice, and d statistical analysis of red area in liver section HE staining (n = 3, 5, 6, 6, 3, 5, 3, respectively) detected 6 h after the indicated treatment with PBS, D-GalN +LPS, GW + D-GalN +LPS, or SR + D-GalN +LPS in WT mice, and PBS, D-GalN +LPS, or GW + D-GalN +LPS in CB2R^−/− mice; e Pathological changes of mouse liver tissue after indicated treatment were examined by HE staining. (ns, P > 0.05; *P < 0.05; ***P < 0.001; ****P < 0.0001)