Table 1.
Effect of A. nilotica extracts on body weight, fasting plasma glucose, fasting plasma insulin, and HOMA-IR index and in the experimental rats.
| Weight loss (%) | Glucose (mg/dL) | Insulin (μIU/mL) | HOMA-IR | |
|---|---|---|---|---|
| Normal | 2.7 ± 2.2 | 62 ± 11 | 2.9 ± 0.7 | 0.4 ± 0.2 |
| HFD Control | 1.4 ± 1.1 | 105 ± 18∗ | 13.3 ± 2.3∗ | 3.5 ± 1.1∗ |
| Orlistat | 28 ± 2∗# | 68 ± 14# | 4.9 ± 1.0∗# | 0.8 ± 0.3∗# |
| Total (250 mg/kg) | 4.2 ± 1.5∗#ˆ | 103 ± 14∗ˆ | 12.1 ± 2.5∗ˆ | 3.1 ± 1∗ˆ |
| Total (500 mg/kg) | 10 ± 3.3∗#ˆ | 92 ± 10∗ˆ | 11.6 ± 2.3∗ˆ | 2.7 ± 0.8∗ˆ |
| EA (250 mg/kg) | 27.8 ± 2.1∗# | 72 ± 7# | 4.5 ± 0.6∗# | 0.8 ± 0.2∗# |
| EA (500 mg/kg) | 31.6 ± 2.3∗# | 64 ± 7# | 3.4 ± 0.6# | 0.5 ± 0.1# |
| Bu (250 mg/kg) | 14.3 ± 1.9∗#ˆ | 92 ± 12∗ˆ | 10.6 ± 1.6∗ˆ | 2.4 ± 0.6∗ˆ |
| Bu (500 mg/kg) | 16 ± 2.6∗#ˆ | 82 ± 11∗#ˆ | 9.1 ± 1.3∗#ˆ | 1.9 ± 0.5∗#ˆ |
EA, ethyl acetate fraction; Bu, butanol fraction. Data are represented as mean ± SD and analyzed by ANOVA followed by Tuckey's post hoc test. ∗ significantly different compared to the normal group; # significantly different compared to the HFD control group; ˆ significantly different compared to the orlistat treated group. Differences were considered significantly different at P < 0.05.