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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Lancet Psychiatry. 2023 Jun;10(6):441–451. doi: 10.1016/S2215-0366(23)00143-8

Figure 4. Polygenic Risk Prediction.

Figure 4.

A comparison of variance explained by polygenic scores (PGS) in single- and multi-PGS models to predict patients from healthy controls, including schizophrenia (SCZ) (A), bipolar disorder (BIP) (B), and BIP with and without psychotic experience (C). Pink represents the single-PGS model with the psychotic-specific PGS and covariates only. Blue represents single-PGS models with covariates and PGS of lifetime cannabis use (LCU) or of cannabis use disorder (CUD). Orange represents the multi-PGS model with the psychotic-specific PGS, LCU- and CUD- PGSs, and covariates. Grey represents comparison models that include the PGS for nonmelanoma skin cancer (NMSC). Significance after Benjamini-Hochberg correction is indicated using * or ns for non-significant.