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. 2022 Jun 20;10(4):1552–1563. doi: 10.1016/j.gendis.2022.05.039

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — 4-OI inhibited the ROS production, thereby inhibiting the activation of MAPK/NF-κB signaling pathway. (A–G) 4-OI significantly reduced the expression levels of p-JNK, p-P38, p-ERK, and p-P65, and promoting the expression of Nrf2/HO-1 in RAW264.7 cells. (H, I) LPS promoted macrophage ROS production and 4-OI inhibited the ROS production in RAW264.7 cells. (J) Flow cytometry results showed that the macrophage purity reached 90%. (K, L) 4-OI significantly inhibited the expression of p-P38, p-ERK, and p-P65, and promote the expression of NRF2/HO-1 in BMDMs. Data are shown as the mean ± SD, ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001.