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Overview of osimertinib resistance mechanisms and corresponding treatment options. Diverse targeting strategies might be available depending on the resistance mechanism. Abbreviations: 4G, fourth generation; 1G, first generation; 2G, second generation; TKI, tyrosine kinase inhibitor; MoA, mechanism of action; ADC, antibody–drug conjugate; amp., amplification; Pt. chemo, platinum-based chemotherapy; ICI, immune checkpoint inhibitor.
