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Exon 3 deletion syndrome phenotype diversity. Shown is the pedigree of a large family with RYR2 exon-3 deletion syndrome; [-] indicates gene-negative individuals; filled circles or squares indicates heterozygous carriers with E3DS phenotype; AF, atrial fibrillation; CRT-D, cardiac resynchronization therapy with implantable cardioverter defibrillator; CRT-P, biventricular pacemaker; DCM–LCNV, dilated cardiomyopathy with left ventricular non-compaction; SCD, sudden cardiac death.
