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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Br J Pharmacol. 2022 Dec 5;180(5):667–680. doi: 10.1111/bph.15903

Figure 3: C781 reduces airway hyperresponsiveness in an acute A. alternata exposure model.

Figure 3:

A concentration response to nebulized methacholine is shown for: (A) Total airway resistance – Rrs; (B) Total airway elastance – Ers; (C) Newtonian resistance – Rn; (D) Tissue damping – G; and (E) Tissue elastance – H. A. alternata (Alt, blue traces) significantly increased responsiveness over both controls (HBSS, black traces or C781 alone, orange traces) and A. alternata supplemented with C781 (Alt + C781, red traces) in all measures tested at the highest methacholine concentrations. * denotes significant difference between Alt and HBSS; # denotes significant difference between Alt and Alt + C781; ^ denotes significant difference between Alt and C781 control; + denotes significant difference between Alt + C781 and C781 control. For Alt (Rn, G, H) and Alt + C781 n = 5; for Alt (Rrs and Ers), HBSS and C781 controls n = 6.